Towards the first synthetic eukaryotic cell  

作　　者：Wangyue Xu Yue Teng Sijie Zhou 

机构地区：[1]Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education),School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China [2]State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing 100071,China [3]Frontiers Research Institute for Synthetic Biology,Tianjin University,Tianjin 300072,China

出　　处：《Biosafety and Health》2024年第6期376-382,共7页生物安全与健康(英文)

基　　金：supported by the National Key Research and Development Program of China(2023YFA0913700);China Postdoctoral Science Foundation(2023 M732591);the Key R&D Program of Shandong Province,China(2022SFGC0102).

摘　　要：With the rapid advance in synthetic biology and the expanding field of synthetic genomics,the realization of a redesigned yeast genome has become an achievable milestone.Multiple eukaryotic chromosomes,meticulously designed and synthesized,are now being systematically integrated to create an entirely synthetic eukaryotic cell.This comprehensive review examines the fundamental design principles and construction strategies,highlighting critical technological breakthroughs in pursuing the first synthetic eukaryotic cell.Additionally,it underscores the critical contributions of the Sc2.0 project,which has provided essential tools and engineered cellular platforms that have significantly accelerated research and industrial progress.The ethical and legal implications arising from synthetic eukaryotic life are also explored,offering insights into future research directions for synthetic eukaryotic genomes.The remarkable advances in deoxyribonucleic acid synthesis hold immense potential,promising to unlock new opportunities across medicine,industry,agriculture,and research.

关 键 词：Synthetic biology Synthetic genomics EUKARYOTES 

分 类 号：R-052[医药卫生]