肉苁蓉提取物抗骨质疏松作用机制研究进展  

Research Progress on the Mechanisms of Action of Cistanche deserticola Ma Extracts in the Prevention of Osteoporosis

作　　者：张秀敏 傅利军 张睿梅 马永征 刘莉 张娜[1] 孙勇 ZHANG Xiumin;FU Lijun;ZHANG Ruimei;MA Yongzheng;LIU Li;ZHANG Na;SUN Yong(College of Food Engineering,Harbin University of Commerce,Harbin 150028,China;Beijing Academy of Food Sciences,Beijing 100068,China)

机构地区：[1]哈尔滨商业大学食品工程学院,黑龙江哈尔滨150028 [2]北京食品科学研究院,北京100068

出　　处：《食品科学》2025年第6期309-319,共11页Food Science

基　　金：“十四五”国家重点研发计划重点专项(2023YFF1104403,2022YFF1100301);河南省重点研发项目(231111112100)。

摘　　要：肉苁蓉(Cistanche deserticola Ma)作为一种传统药食同源植物,因其较低的毒性和较少的副作用在预防和治疗骨质疏松症方面显示出独特优势。肉苁蓉能够改善骨密度和骨量下降,促进成骨细胞活性和抑制破骨细胞功能调节骨代谢,尤其在保护骨微结构方面表现突出,可以全面增强骨骼内部架构的稳定性,降低骨折风险。本文旨在综述肉苁蓉抗骨质疏松的药效作用和分子机制,通过分析已有研究成果,揭示肉苁蓉在调控骨重建过程中的潜在机理及其临床应用前景,以期为肉苁蓉功能食品开发及临床应用提供重要参考。Cistanche deserticola Ma is a traditional medicinal and edible plant that has demonstrated significant potential for the prevention and treatment of osteoporosis in recent years.Conventional medications for osteoporosis,including bisphosphonates,calcitriol,and VD,may induce various adverse reactions and increase the physiological burden on patients when used long-term.In contrast,C.deserticola offers unique advantages due to its lower toxicity and fewer side effects,making it particularly suitable for osteoporosis management.Research indicates that C.deserticola effectively mitigates the loss of bone density and bone mass.It regulates bone metabolism by enhancing osteoblast activity and inhibiting osteoclast function,thereby preserving bone microarchitecture and consequently enhancing the overall stability of the internal bone structure and reducing the risk of fractures.This review aims to summarize the pharmacological effects and molecular mechanisms of C.deserticola in combating osteoporosis.By systematically reviewing and analyzing existing literature,we seek to elucidate the potential mechanisms through which C.deserticola modulates bone remodeling and to explore its prospects for clinical application.The insights gained from this study are intended to provide an important reference for the development and clinical application of functional foods derived from C.deserticola.

关 键 词：肉苁蓉 药食同源 骨质疏松症 骨代谢 作用机制 

分 类 号：TS201.4[轻工技术与工程—食品科学]