An Intelligent Triple Assisted Gold Cluster-Based Nanosystem for Enhanced Tumor Photodynamic Therapy  

作　　者：Fangli Gao Yanru Liu Liang Zhu Jie Zhang Yi Chang Weihua Gao Guanglei Ma Xiaoming Ma Yuming Guo 

机构地区：[1]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan,453007 China [2]Key Laboratory of Green Chemical Media and Reactions,Ministry of Education,Henan Normal University,Xinxiang,Henan,453007 China [3]Henan International Joint Laboratory of Smart Molecules and Identification and Diagnostic Functions,Henan Normal University,Xinxiang,Henan,453007 China

出　　处：《Chinese Journal of Chemistry》2025年第2期175-183,共9页中国化学(英文版)

基　　金：financially supported by the National Natural Science Foundation of China(21771058 and 21877027);the Natural Science Foundation of Henan Province(242300421205,212300410009,and 232300421302);the 111 Project(D17007),the Program for Science&Technology Innovation Talents in Universities of Henan Province(23HASTIT002);the Foundation of Henan Educational Committee(23A150021).

摘　　要：Photodynamic therapy (PDT) has been attracted a surge of research interest. However, there are several obstacles to limit the efficacy of PDT, such as hypoxic tumor microenvironment (TME), overexpressed glutathione (GSH), inefficient reactive oxygen species (ROS) generation, and so on. Herein, a smart responsive nanosystem was constructed, which was composed of Au25 modified with triphenylphosphine (Au25-TPP), catalase (CAT) and GSH-responsive diselenide-bridged mesoporous silica nanoparticles (Se-MSN). When the nanosystem arrived at tumor site, Se-MSN was degraded by the intracellular overexpressed GSH to release Au25-TPP and CAT. The Au25-TPP was targeted to mitochondria and generated ROS under the 808 nm NIR laser irradiation to kill tumor cells. Simultaneously, CAT could catalyze hydrogen peroxide to provide oxygen for relieving the hypoxia of TME. Besides, GSH was consumed by the diselenide bond to diminish the ROS loss. The above tactics (mitochondria targeting, hypoxia relieving and GSH consuming) jointly enhanced the PDT efficacy. The nanosystem showed distinct in vitro anticancer effect significantly stronger than other groups containing one or two assistance. Moreover, the in vivo results suggested that the tumors could be restrained obviously. The current study provides a new inspiration for constructing novel inorganic nanomedicines with multiple enhancement effect of PDT efficacy.

关 键 词：Gold nanoclusters Diselenide-bridged mesoporous silica nanoparticles HYPOXIA Photodynamic therapy CATALASE GSH consuming Mitochondrial targeting Tumor therapy Bioinorganic chemistry Cancer treatment Drug nanocarrier 

分 类 号：R73[医药卫生—肿瘤]