Single-cell transcriptomics illustrates the immune inflammatory responses of septic mice spleen after capsaicin treatment  

作　　者：Weijin Qiu Qian Zhang Jing Liu Xueling He Guangqing Cheng Jiayun Chen Yunmeng Bai Piao Luo Ping Gong Fei Shi Jigang Wang 

机构地区：[1]Department of Emergency,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong 518020,China [2]School of Traditional Chinese Medicine and School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong 510515,China [3]State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China [4]Department of Infectious Disease,Shenzhen People's Hospital,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong 518020,China [5]State Key Laboratory of Antiviral Drugs,School of Pharmacy,Henan University,Kaifeng,Henan 475004,China

出　　处：《Genes & Diseases》2025年第1期9-13,共5页基因与疾病(英文)

基　　金：supported by the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research(No.2020YFE0205100);the National Key Research and Development Program of China(No.2020YFA0908000);the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(China)(No.ZYYCXTD-C-202002);the National Natural Science Foundation of China(No.82074098,81841001);the Fundamental ResearchFunds for the Central Public Welfare Research Institutes(China)(No.ZZ13-ZD-07,ZXKT18003,ZZ14-YQ-050,ZZ14-ND-010,ZZ15-ND-10,ZZ14-FL-002,ZZ14-YQ059,ZZ15-YQ-063);Shenzhen Science and Technology Innovation Commission(Guangdong,China)(No.JCYJ20210324115800001 and JCYJ20210324114014039);the National Key R&D Program of China Key projects for international cooperation on science,technology and innovation(No.2020YFE0205100);the Shenzhen Medical Research Fund of Shenzhen Medical Academy of Research and Translation(Guangdong,China)(No.B2302051);the Distinguished Expert Project of Sichuan Province Tianfu Scholar(China)(No.CW202002);China Academy of Chinese MedicalSciencess(CACMS)InnovationFund(No.CI2023E002);State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs.

摘　　要：Sepsis,a life-threatening condition triggered by a dysregulated host response to infection,remains a major challenge for therapeutic intervention.Despite the growing interest in immunomodulatory strategies for sepsis treatment,the effects and mechanisms of these approaches on the organ-specific inflammatory and immunosuppressive states induced by sepsis are poorly understood.According to existing studies,capsaicin(CPS)has pharmacological effects such as analgesic,antipruritic,hypolipidemia,hypoglycemia,anti-inflammatory and antibacterial,and antitumor activity.1 However,the effectiveness of CPs in treating sepsis is still unknown.

关 键 词：inflammatory CAPSAICIN TREATMENT 

分 类 号：R392[医药卫生—免疫学]