Prevalence of synonymous mutations in m^(6)A modification sites in human cancers  

作　　者：Richard Chen Lu Yang Li Han Zunsong Hu Zhaohui Gu Xiaolan Deng 

机构地区：[1]Department of Systems Biology,Beckman Research Institute of City of Hope,Monrovia,CA 91016,USA [2]Department of Computational and Quantitative Medicine,Beckman Research Institute of City of Hope,Monrovia,CA 91016,USA [3]South Pasadena High School,1401 Fremont Ave,South Pasadena,CA 91030,USA [4]Center for RNA Biology and Therapeutics,City of Hope,Duarte,CA 91010,USA [5]School of Pharmacy,China Medical University,Shenyang,Liaoning 110001,China

出　　处：《Genes & Diseases》2025年第1期148-150,共3页基因与疾病(英文)

基　　金：supported in part by the Eugene and Ruth Roberts Summer Student Academy Program of City of Hope(to R.C.).

摘　　要：As one amino acid can often be encoded by multiple codons,the genetic code is redundant,which accounts for synonymous mutations in protein-coding regions.1 Since synonymous mutations do not cause any alterations in amino acid sequence,it was previously believed that they do not change the structure and function of the proteins and thus are functionally silent.1 However,evidence is emerging that synonymous mutations can affect messenger RNA(mRNA)stability,splicing and translation,and thereby influencing protein biogenesis.1 Nevertheless,the detailed mechanisms underlying the impacts of synonymous mutations on mRNA metabolism and protein biogenesis remain elusive.

关 键 词：thereby REDUNDANT STABILITY 

分 类 号：R730.2[医药卫生—肿瘤]