Known and unknown:Exosome secretion in tumor microenvironment needs more exploration  

作　　者：Mengxiang Huang Jie Ji Xuebing Xu Dandan Jin Tong Wu Renjie Lin Yuxuan Huang Jiawen Qian Zhonghua Tan Feng Jiang Xiaogang Hu Weisong Xu Mingbing Xiao 

机构地区：[1]Department of Gastroenterology,Affiliated Hospital of Nantong University,Medical School of Nantong University,Nantong,Jiangsu 226001,China [2]Clinical Medicine,Medical School of Nantong University,Nantong,Jiangsu 226001,China [3]Department of Nuclear Medicine,Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001,China [4]Department of Respiratory Medicine,Rudong County People’s Hospital,Nantong,Jiangsu 226400,China [5]Department of Gastroenterology,Affiliated Nantong Rehabilitation Hospital of Nantong University,Nantong,Jiangsu 226001,China

出　　处：《Genes & Diseases》2025年第1期158-171,共14页基因与疾病(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(No.82272624);the Natural Science Foundation of Jiangsu Province,China(No.BK20211105);the Plan of Jiangsu Provincial Medical Key Discipline(China)(No.ZDXK202240);the Social Development Foundation of Nantong City,Jiangsu,China(No.MS22022044,JC22022001,JCZ2022027);the Health Project of Nantong City,Jiangsu,China(No.MS2022056);the Postgraduate Research and Practice Innovation Program of Jiangsu Province,China(No.SJCX21_1452,KYCX21_3112,KYCX23_3419);Jiangsu Provincial Research Hospital(China)(YJXYY202204);the Jiangsu Administration of Traditional Chinese Medicine(China)(JD2022SZ07);Teaching Research Project of Affiliated Hospital of Nantong University(China)(Tfj22002).

摘　　要：Exosomes,extracellular vesicles originating from endosomes,were discovered in the late 1980s and their function in intercellular communication has since garnered considerable interest.Exosomes are lipid bilayer-coated vesicles that range in size from 30 to 150 nm and appear as sacs under the electron microscope.Exosome secretion is crucial for cell-to-cell contact in both normal physiology and the development and spread of tumors.Furthermore,cancer cells can secrete more exosomes than normal cells.Scientists believe that intercellular communication in the complex tissue environment of the human body is an important reason for cancer cell invasion and metastasis.For example,some particles containing regulatory molecules are secreted in the tumor microenvironment,including exosomes.Then the contents of exosomes can be released by donor cells into the environment and interact with recipient cells to promote the migration and invasion of tumor cells.Therefore,in this review,we summarized the biogenesis of exosome,as well as exosome cargo and related roles.More importantly,this review introduces and discusses the factors that have been reported to affect exosome secretion in tumors and highlights the important role of exosomes in tumors.

关 键 词：Exosome cargo Exosome secretion Intercellular communication TUMOR Tumor microenvironment 

分 类 号：R730.2[医药卫生—肿瘤]