TIR-mediated immune signaling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicots  

作　　者：Natsumi Maruta Mitchell Sorbello Bostjan Kobe 

机构地区：[1]School of Chemistry and Molecular Biosciences,University of Queensland,Brisbane,QLD 4072,Australia [2]Australian Infectious Diseases Research Centre,University of Queensland,Brisbane,QLD 4072,Australia [3]Institute for Molecular Bioscience,University of Queensland,Brisbane,QLD 4072,Australia

出　　处：《Molecular Plant》2025年第2期192-194,共3页分子植物(英文版)

基　　金：B.K's laboratory was funded by the National Health and Medical Research Council(NHMRC Australia;Investigator grant 2025931);the Australian Research Council(ARC;Discovery Project DP220102832).

摘　　要：Plants defend themselves against pathogens by activating two interconnected layers of immunity:pattern-and effector-triggered immunity.Recent studies shed light on a number of unanswered questions in these pathways and demonstrate a conserved structural basis,in monocots and dicots,of signaling through the EDS1:PAD4:ADR1 module,downstream of Toll/interleukin-1 receptor(TIR)domain-containing immune receptors that cleave the dinucleotide nicotinamide adenine dinucleotide(NAD+).The studies define a new function for TIR domain proteins in monocots and suggest that the signaling molecule 5″-phosphoribosyl(pRib)-AMP is derived from the TIR product 2′-adenosine diphosphate ribose(2′cADPR).These findings have important implications for developing the strategies to breed resistant crops.

关 键 词：PAD4 DINUCLEOTIDE MONO 

分 类 号：G63[文化科学—教育学]