DINUCLEOTIDE

作品数：41被引量：89H指数：5
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相关领域：生物学更多>>
相关作者：赵明峰陈洁杨定平陆祖宏孙啸更多>>
相关机构：天津市第一中心医院武汉大学广东医科大学东南大学更多>>
相关期刊：《中华高血压杂志（中英文）》《Science China(Life Sciences)》《Science China Chemistry》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金天津市自然科学基金国家重点基础研究发展计划The Royal Society更多>>
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TIR-mediated immune signaling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicots
《Molecular Plant》2025年第2期192-194,共3页Natsumi Maruta Mitchell Sorbello Bostjan Kobe 
B.K's laboratory was funded by the National Health and Medical Research Council(NHMRC Australia;Investigator grant 2025931);the Australian Research Council(ARC;Discovery Project DP220102832).
Plants defend themselves against pathogens by activating two interconnected layers of immunity:pattern-and effector-triggered immunity.Recent studies shed light on a number of unanswered questions in these pathways an...
关键词：PAD4 DINUCLEOTIDE MONO 
NAD(P)H inspired CO_(2) reduction and beyond
《Science China Chemistry》2024年第4期1044-1046,共3页Wenjin Dong Jian Liu 
The catalytic reduction of carbon dioxide to fuels and valueadded chemicals under mild conditions is recognized as a promising strategy to alleviate the energy crisis.In the Calvin cycle of natural photosynthesis,CO_(...
关键词：dioxide DINUCLEOTIDE CATALYST 
Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies
《Cancer Biology & Medicine》2024年第1期45-64,共20页Jiawen Zhang Sihui Yu Qiao Peng Ping Wang Lan Fang 
the National Key Research and Development Program of China(Grant Nos.2022YFC3401500 and 2020YFA0803201 to P.W.,and 2021YFA1302200 to L.F.);the National Natural Science Foundation of China(Grant Nos.31830053,31920103007,and 82341028 to P.W.;82122056,82073153,and 31871398 to L.F.and 31900568 to P.W.);the Natural Science Foundation of Shanghai(Grant No.22ZR1450700 to Z.J.W.)。
The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment.Within this landscape,the innate immune system,a critical sentinel prote...
关键词：cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy 
Cyclic Dinucleotide Self-Assembled Nanoparticles as a Carrier-Free Delivery Platform for STING-Mediated Cancer Immunotherapy被引量：1
《CCS Chemistry》2024年第1期177-195,共19页Lang Zhao Shao-Hua Zhuo Tian-Yang Wang Jun-Jun Wu Jing-Yun Su Wen-Hao Li Bo-Dou Zhang Yan-Mei Li 
the National Key R&D Program of China(grant nos.2019YFA0904200 and 2018YFA0507600);the National Natural Science Foundation of China(grant nos.22237003 and 92053108);the Tsinghua University Spring Breeze Fund(grant no.2020Z99CFY042).
Cyclic dinucleotides(CDNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy target.Currently,CDNs and their derivatives are being investigated clinically.However,th...
关键词：cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy 
Structural Insights into Folate Transporter May Offer Clues for Anticancer Drugs
《Bulletin of the Chinese Academy of Sciences》2022年第4期226-227,共2页YAN Fusheng 
Researchers from the CAS Institute of Biophysics(IOB)have discovered that the transport protein SLC19A1,traditionally known for transporting B9 vitamins and antifolate drugs,is also a transporter of cyclic dinucleotid...
关键词：DINUCLEOTIDE system FUNCTION 
Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy被引量：3
《Bioactive Materials》2022年第10期1-11,共11页Huan Zheng Beibei Guo Xinyun Qiu Yifeng Xia Yan Qu Liang Cheng Fenghua Meng Zhiyuan Zhong 
supported by research grants from the National Natural Science Foundation of China(NSFC 52033006,51861145310,51773146 and 51633005)and the National Key R&D Program of China(2021YFB3800900).
Cyclic dinucleotides(CDNs)as stimulator of interferon genes(STING)agonists capable of inducing strong antitumor innate immune response are highly promising for tumor immunotherapy.The efficacy of these CDNs is,however...
关键词：POLYMERSOMES STING agonists Cyclic dinucleotide Immunotherapy Radiotherapy 
Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide被引量：5
《Science China(Life Sciences)》2021年第8期1355-1367,共13页Zhiquan Liu Siyu Chen Yingqi Jia Huanhuan Shan Mao Chen Yuning Song Liangxue Lai Zhanjun Li 
financially supported by the National Key Research and Development Program of China Stem Cell and Translational Research (2019YFA0110700);the Program for Changjiang Scholars and Innovative Research Team in University (IRT16R32);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030501, XDA16030503);Key Research & Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (2018GZR110104004)
Cytidine base editor(CBE),which is composed of a cytidine deaminase fused to Cas9 nickase,has been widely used to induce C-to-T conversions in a wide range of organisms.However,the targeting scope of current CBEs is l...
关键词：BASE EDITOR compatibility 
Roles of AKR1C3 in malignancy被引量：2
《Chinese Medical Journal》2021年第9期1052-1054,共3页Xin-Zhu Xiao Li-Ying Lin Ming-Kai Zhuang Can-Mei Zhong Feng-Lin Chen 
supported by the Medical Innovation Project of Fujian Province(No.2019-CX-14);the Joint Funds for the Innovation of Science and Technology,Fujian province(No.2019Y9083);the Fujian Medical University Cancer Center and the Key Clinical Specialty Discipline Construction Program of Fujian,China(No.Min Wei Ke Jiao 2012 No.149)。
The superfamily of aldo-keto reductases(AKRs)is composed of over 190 members and can be classified into 16 different families(visit www.med.upenn.edu/akr).AKR1C3(C3 subtype of aldosterone reductase family 1)refers to ...
关键词：DINUCLEOTIDE AKR1C3 ADENINE 
Intensifying Electron Utilization by Surface-Anchored Rh Complex for Enhanced Nicotinamide Cofactor Regeneration and Photoenzymatic CO_(2)Reduction被引量：6
《Research》2021年第1期507-517,共11页Yuqing Cheng Jiafu Shi Yizhou Wu Xueying Wang Yiying Sun Ziyi Cai Yu Chen Zhongyi Jiang 
supported by the National Natural Science Funds of China(21776213 and 21621004);the Natural Science Fund of Tianjin(19JCYBJC19700);the Open Funding Project of the State Key Laboratory of Biochemical Engineering(2020KF-06);the Open Funding Project of the State Key Laboratory of Chemical Engineering(SKL-ChE19B01);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(TSBICIP-KJGG-003);the Royal Society International Collaboration Award(ICA\R1\180317)for the financial support.
Solar-driven photocatalytic regeneration of cofactors,including reduced nicotinamide adenine dinucleotide(NADH),reduced nicotinamide adenine dinucleotide phosphate(NADPH),and reduced flavin adenine dinucleotide(FADH_(...
关键词：ENZYMATIC DINUCLEOTIDE CATALYST 
Genome-wide evolution analysis reveals low CpG contents of fast-evolving genes and identifies antiviral microRNAs被引量：1
《Journal of Genetics and Genomics》2020年第1期49-60,共12页Wenhong Zu Hang Zhang Xun Lan Xu Tan 
supported by the National Natural Science Foundation of China (Grant No. 31670777);the China National Funds for Distinguished Young Scientists (Grant No. 31722030);the Beijing Advanced Innovation Center for Structural Biology to X.T.;the Tsinghua-Peking Joint Center for Life Sciences (Grant No. 61020100119);the National Thousand Young Talents Program of China (Grant No. 042021011) to X.L.
Noncoding RNAs(ncRNAs) play important roles in many biological processes and provide materials for evolutionary adaptations beyond protein-coding genes, such as in the arms race between the host and pathogen. However,...
关键词：Host-virus interaction Positive selection CPG DINUCLEOTIDE Noncoding RNA MicroRNA 
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