Unraveling the molecular mechanisms behind tight junction belt formation  

揭示紧密连接带形成的分子机制

作　　者：Ziran Qin Jing Zou Long Zhang 秦子然;邹婧;张龙

机构地区：[1]State Key Laboratory of Transvascular Implantation Devices of the Second Affiliated Hospital of the Zhejiang University School of Medicine,Zhejiang University,Hangzhou 310009,China [2]MOE Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [3]Cancer Center,Zhejiang University,Hangzhou 310058,China

出　　处：《Science Bulletin》2025年第4期441-443,共3页科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(31925013,U20A20393 and W2411011);a special programme from the Ministery of Science and Technology of China(2021YFA1101000);a Key R&D Program of Zhejiang Province(2024C03142);the Joint Project of Pinnacle Disciplinary Group,the Second Affiliated Hospital of Chongqing Medical.

摘　　要：Tight junctions are crucial intercellular connections between epithelial and certain endothelial cells that play a vital role in maintaining cell polarity,regulating paracellular permeability,and preventing pathogens from crossing the epithelial and endothelial layers[1],[2],[3].Tight junction dysfunction is associated with various diseases,including inflammatory bowel disease,tumor metastasis,and neurodegenerative diseases[4].Therefore,a deeper understanding of the regulatory mechanisms of tight junctions is important for disease prevention and treatment.Researchers have identified key proteins necessary for the formation and positioning of tight junctions using genetic and biochemical approaches;these include adhesion receptors from the claudin family and two scaffold proteins,zonula occludens proteins ZO1 and ZO2[5],[6].Previous studies have shown that the phase separation of ZO proteins into a condensed,membrane-bound phase is essential for claudin receptor organization and tight junction formation[7],[8].However,tight junctions must maintain stability under diverse physiological and pathological conditions while also being capable of swiftly responding to environmental shifts.How they achieve this balance between stability and plasticity,and the regulatory mechanisms underlying this equilibrium,pose significant scientific questions.

关 键 词：PREVENTION MECHANISMS TIGHT 

分 类 号：R73[医药卫生—肿瘤]