Chronic implantable flexible serpentine probe reveals impaired spatial coding of place cells in epilepsy  

作　　者：Yu Wang Meiqi Han Zhaojie Xu Shiya Lv Gucheng Yang Fan Mo Luyi Jing Qianli Jia Yiming Duan Wei Xu Peiyao Jiao Yaoyao Liu Jin Shan Ming Li Mixia Wang Jinping Luo Yilin Song Juntao Liu Yirong Wu Xinxia Cai 

机构地区：[1]State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China [2]School of Electronic,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《National Science Review》2025年第2期280-293,共14页国家科学评论(英文版)

基　　金：supported by the National Natural Science Foundation of China(62121003,T2293730,T2293731,61960206012,L2224042,62333020 and 62171434);STI 2030–Major Projects(2021ZD0201603);the National Key Research and Development Program of China(2022YFC2402501 and 2022YFB3205602);Frontier Interdiscipline Project of the Chinese Academy of Sciences(XK2022XXC003).

摘　　要：The development of minimally invasive and reliable electrode probes for neural signal recording is crucial for advancing neuroscience and treating major brain disorders.Flexible neural probes offer superior long-term recording capabilities over traditional rigid probes.This study introduces a parylene-based serpentine electrode probe for stable,long-term neural monitoring.Inspired by the flexibility and morphology of snakes,the serpentine design of the probe ensures stable anchorage within the brain tissue during subject movement.The probe features a hydrophilic surface and is combined with a biodegradable silk fibroin-polyethylene glycol coating,significantly enhancing biocompatibility and mitigating inflammatory responses.In vivo experiments demonstrate that these probes enable stable,high-quality neural recordings for>8 months.The probes are also used to investigate the neural bases of epilepsy-induced cognitive deficits.By analysing place-cell dynamics in mice pre-and post-epileptic events,we identified the correlation between impaired spatial encoding and the observed cognitive deficits in epileptic mice.This study highlights the potential of our flexible probes in neurological research and medical applications.

关 键 词：flexible probe EPILEPSY chronic neural recording place cell biocompatible surface 

分 类 号：R74[医药卫生—神经病学与精神病学]