IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells  

作　　者：Soojeong Noh Suyeon Ryu Dokyung Jung Sanghee Shin Inseong Jung Sung-Min Kang Christine Seulki Kim Sung-Jin Choi Hanchae Cho Melanie Schwammle Youngtae Jeong Felicitas Bucher Il-Kyu Choi Shin Yup Lee Sin-Hyeog Im Kyungmoo Yea Moon-Chang Baek 

机构地区：[1]Department of New Biology,DGIST,Daegu,Republic of Korea [2]Department of Molecular Medicine,Cell and Matrix Research Institute(CMRI),School of Medicine,Kyungpook National University,Daegu,Republic of Korea [3]Department of Molecular Medicine,Kyungpook National University,Daegu,Republic of Korea [4]Faculty of Biology,University of Freiburg,Freiburg im Breisgau,Germany [5]Eye Center,Medical Center,Faculty of Medicine,University of Freiburg,Freiburg im Breisgau,Germany [6]New Biology Research Center,DGIST,Daegu,Republic of Korea [7]Department of Internal Medicine,School of Medicine,Kyungpook National University,Daegu,Republic of Korea [8]Lung Cancer Center,Kyungpook National University Chilgok Hospital,Daegu,Republic of Korea [9]Department of Life Sciences,Pohang University of Science and Technology,Pohang,Republic of Korea

出　　处：《Cancer Communications》2024年第12期1422-1426,共5页癌症通讯(英文)

基　　金：supported by the Bio&Medical Technology Development Program of the National Research Foundation(NRF)of Korea funded by the Korean government(MSIT)(2022R1A2C109214511 and 2020M3A9I4039539);the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(2021R1A5A2021614,2023R1A2C3005553);the DGIST Program of the Ministry of Science and ICT(21-DGRIP-01).

摘　　要：Cancer cells secrete small extracellular vesicles(sEVs)to regulate various cellular functions,like tumor growth and metastasis,by promoting epithelial-mesenchymal transition and angiogenesis[1,2].Additionally,cancer cells evade immune surveillance by upregulating the surface expression of cellular programmed death-ligand 1(cPDL1),which interacts with programmed cell death-1(PD-1)on cytotoxic T cells,suppressing immune responses[3].

关 键 词：PDL1 CANCER CANCER 

分 类 号：R73[医药卫生—肿瘤]