Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets  

作　　者：Dongxu Ming Xincong Xu Xianren Jiang Yanpin Li Wenjuan Sun Jiangbo Xiang Mingyuan Huang Yu Pi Xilong Li 

机构地区：[1]Boen Group Co.,Ltd.,Ganzhou 341000,China [2]Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs,Institute of Feed Research,Chinese Academy of Agricultural Sciences,Beijing 100081,China

出　　处：《Animal Nutrition》2024年第4期240-247,共8页动物营养(英文版)

基　　金：financially supported by the Science and Technology Program of Shijiazhuang City(236490539A);the China Postdoctoral Science Foundation(2023M730594);the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences(CAAS-ZDRW202305);the Agricultural Science and Technology Innovation Program of the Feed Research Institute of the Chinese Academy of Agricultural Sciences(CAASIFR-ZDRW202302).

摘　　要：Indole-3-propionic acid(IPA)has anti-inflammatory properties,which can be beneficial for weaned piglets with underdeveloped immune systems.The study explores the impact of IPA supplementation on growth performance,oxidative stress,and inflammation response in weaned piglets.In Exp.1,90 weaned piglets were divided into six groups(5 replicates per group,3 pigs per replicate),with each group receiving a basal diet with varying amounts of IPA(0,50,100,200,400,or 600 mg/kg)for 42 d.Piglets fed the diets with 50,100,and 200 mg/kg of IPA exhibited reduced feed conversion ratios(F:G)compared to the control piglets(P=0.035).Notably,50 and 100 mg/kg IPA treatments significantly reduced diarrhea incidence and serum interleukin(IL)-6 content(P<0.05).Conversely,a high dosage of 600 mg/kg IPA led to increased serum contents of tumor necrosis factor(TNF)-α,and IL-6(P<0.05).Optimal antioxidant benefits were observed at 100 mg/kg IPA supplementation,which significantly reduced malondialdehyde levels while enhancing serum total antioxidant capacity and total superoxide dismutase activity on d 14(P<0.05).Exp.2 investigated the effects of IPA on lipopolysaccharide(LPS)challenge in weaned piglets.The study consisted of 32 weaned piglets allocated into 4 groups,with 8 replicates per group and 1 piglet per replicate:a control group,a LPS challenge group,a LPS challenge group supplemented with 100 mg/kg IPA,and a group supplemented with 100 mg/kg IPA alone.Upon administration of LPS or saline injection,the results indicated that dietary IPA supplementation in challenged piglets enhanced villus height:crypt depth,modulated IL-8 and IL-22 mRNA relative expression,and increased the tight junction protein claudin-1 mRNA relative expression in the intestinal mucosa(P<0.05).These findings suggest that dietary supplementation of IPA at specific concentrations significantly improves growth performance,reduces diarrhea incidence,and mitigates inflammation and oxidative stress in weaned piglets.It may be concluded that incorporating IPA into the

关 键 词：Indole-3-propionic acid IMMUNOREGULATION ANTIOXIDATION Intestinal health PIGLET 

分 类 号：R57[医药卫生—消化系统]