A novel Au(III)agent designed to inhibit tumor growth and metastasis through inducing immunogenic cell death  

作　　者：Wen-Juan Li Shan-He Li Xue-Yu Man Gang Xu Zhen-Lei Zhang Yao Zhang Hong Liang Feng Yang 

机构地区：[1]State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China),Collaborative Innovation Center for Guangxi Ethnic Medicine,School of Chemistry and Pharmaceutical Sciences,Guangxi Normal University,Guilin,541004,China [2]Department of Biochemistry and Molecular Biology,Michigan State University,East Lansing,48824,USA

出　　处：《Rare Metals》2025年第1期430-443,共14页稀有金属(英文版)

基　　金：supported by the Natural Science Foundation of Guangxi(No.2022GXNSFGA035003);the National Natural Science Foundation of China(No.22077021).

摘　　要：To treat cancer and inhibit its metastasis to the greatest extent,we proposed to develop an Au(III)agent to induce immunogenic cell death(ICD)and establish long-term immunity.To this end,we optimized a series of Au(III)2-benzoylpyridine thiosemicarbazone complexes to obtain an Au(III)agent(5b)with excellent cytotoxicity to cancer.The results show that 5b effectively inhibits tumor growth and its metastasis in vivo.Interestingly,we revealed a new mechanism of 5b inhibiting tumor growth and metastasis:5b releases ICD-related damage-associated molecular patterns(DAMPs),such as calreticulin(CRT),ATP and high mobility group box 1(HMGB1)by inducing endoplasmic reticulum stress(ERS)and mitochondrial dysfunction,which then stimulated an antitumor CD8+T cell response and Foxp^(3+)T cell depletion,thus establishing long-action antitumor immunity.

关 键 词：Gold complex ANTICANCER THIOSEMICARBAZONE Endoplasmic reticulum stress Immunogenic cell death 

分 类 号：R73[医药卫生—肿瘤]