伴中央颞区棘波的自限性癫痫出现睡眠中癫痫电持续状态的危险因素分析及列线图预测模型构建  

Risk factors analysis and prediction model construction of self-limited epilepsy with centrotemporal spikes compilcated by electrical status epilepticus during sleep

作　　者：卢晓庆 甘玲[1] 郭芪良 张晓莉[1] 李小丽[1] 关静 连子硕 王海艳[1] 张亚 李林[1] 贾天明[1] LU Xiaoqing;GAN Ling;GUO Qiliang;ZHANG Xiaoli;LI Xiaoli;GUAN Jing;LIAN Zishuo;WANG Haiyan;ZHANG Ya;LI Lin;JIA Tianming(Department of Pediatric Neurology,the Third Afiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院小儿神经内科,郑州450052

出　　处：《癫痫杂志》2025年第2期121-126,共6页Journal of Epilepsy

摘　　要：目的分析伴中央颞区棘波的自限性癫痫(self-limited epilepsy with centrotemporal spikes,SeLECTs)患者出现睡眠中癫痫电持续状态(electrical status epilepticus during sleep,ESES)的风险因素,并构建列线图模型。方法本研究选取了2017年3月—2024年3月期间,就诊于郑州大学第三附属医院且病例资料齐全的174例SeLECTs患儿作为研究对象。根据病程中视频脑电图监测结果,将患儿分为无ESES组(88例)和ESES组(86例),采用多因素logistic回归分析,识别了SeLECTs患者出现ESES的风险因素。结果多因素二元logistic回归分析结果显示治疗前脑电图双侧分布、发作形式以及初始治疗后癫痫发作是出现ESES的危险因素。结论治疗前脑电图放电双侧分布、出现新的发作形式、初始治疗后癫痫发作是SeLECTs患者出现ESES的危险因素,构建的基于上述危险因素的列线图模型具有较高的准确度。Objective To analyze the risk factors for electrical status epilepticus during sleep(ESES)in patients with self-limited epilepsy with centrotemporal spikes(SeLECTs)and to construct a nomogram model.Methods This study selected 174 children with SeLECTs who visited the Third Affiliated Hospital of Zhengzhou University from March 2017 to March 2024 and had complete case data as the research subjects.According to the results of video electroencephalogram monitoring during the course of the disease,the children were divided into non-ESES group(88 cases)and ESES group(86 cases).Multivariate logistic regression analysis was used to identify the risk factors for the occurrence of ESES in SeLECTs patients.Results The multifactor Logistic regression analysis demonstrated that the EEG discharges in bilateral cerebral areas,types of seizure,epileptic seizures after initial treatment were the independent risk factors for the occurrence of ESES in SeLECTs.Conclusion Bilateral distribution of electroencephalogram discharges before treatment,emergence of new seizure forms,and epileptic seizures after initial treatment are risk factors for the ESES in SeLECTs patients.The nomogram model constructed based on the above risk factors has a high degree of accuracy.

关 键 词：伴中央颞区棘波的自限性癫痫 睡眠中癫痫电持续状态 危险因素 列线图 预测模型 

分 类 号：R74[医药卫生—神经病学与精神病学]