Advances in cervical cancer:current insights and future directions  

作　　者：Miaochun Xu Canhui Cao Peng Wu Xiaoyuan Huang Ding Ma 

机构地区：[1]Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,P.R.China [2]National Clinical Research Center for Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,P.R.China [3]Cancer Biology Research Center(Key Laboratory of the Ministry of Education),Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,P.R.China [4]Department of Gynecologic Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,P.R.China

出　　处：《Cancer Communications》2025年第2期77-109,共33页癌症通讯(英文)

基　　金：National Key R&D Program of China,Grant/Award Number:2021YFC2701201;Natural Science Foundation of China,Grant/Award Numbers:82072895,82372929,82141106,82203453;Foundation of Tongji Hospital of HUST,China,Grant/Award Numbers:2023CXZH014,24-2KYC13057-08。

摘　　要：In alignment with the World Health Organization’s strategy to eliminate cervical cancer,substantial progress has been made in the treatment of this malignancy.Cervical cancer,largely driven by human papillomavirus(HPV)infection,is considered preventable and manageable because of its well-established etiology.Advancements in precision screening technologies,such as DNA methylation triage,HPV integration detection,liquid biopsies,and artificial intelligenceassisted diagnostics,have augmented traditional screening methods such as HPV nucleic acid testing and cytology.Therapeutic strategies aimed at eradicating HPV and reversing precancerous lesions have been refined as pivotal measures for disease prevention.The controversy surrounding surgery for early-stage cervical cancer revolves around identifying optimal candidates for minimally invasive and conservative procedures without compromising oncological outcomes.Recent clinical trials have yielded promising results for the development of systemic therapies for advanced cervical cancer.Immunotherapies,such as immune checkpoint inhibitors(ICIs),antibody-drug conjugates(ADCs),and targeted therapy have demonstrated significant effectiveness,marking a substantial advancement in cervical cancer management.Various combination therapies have been validated,and ongoing trials aim to enhance outcomes through the development of novel drugs and optimized combination regimens.The prospect of eradicating cervical cancer as the first malignancy to be eliminated is now within reach.In this review,we provide a comprehensive overview of the latest scientific insights,with a particular focus on precision managements for various stages of cervical disease,and explore future research directions in cervical cancer.

关 键 词：cervical cancer CARCINOGENESIS clinical trials human papillomavirus IMMUNOTHERAPY precision medicine screening strategies targeted therapy therapeutic advancements 

分 类 号：R73[医药卫生—肿瘤]