From biological potency absorbed components to artificial intelligence mining:a review of analytical strategies for the discovery and validation of quality marker in traditional Chinese medicine in the past decade  

作　　者：Ziting Li Yi Dai 

机构地区：[1]Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE),Jinan University,Guangzhou,China [2]Department of Radiology,the First Affiliated Hospital of Jinan University,Guangzhou,China

出　　处：《Guideline and Standard in Chinese Medicine》2024年第4期156-166,共11页中医规范与标准(英文)

基　　金：funded by the National Natural Science Foundation of China(U23A20500).

摘　　要：Quality control of traditional Chinese medicine(TCM)is fundamental to ensuring its clinical efficacy,with TCM formulas being the primary form used in clinical practice.Current quality control methods for TCM formulas often rely on pharmacopoeial standards for individual medicinal materials,typically encompassing only characteristic or partial active ingredients.These methods fail to fully reflect the clinical efficacy of TCM formulas.Consequently,exploring the multiple efficacious components in TCM formulas and establishing the correlation between multicomponent content and efficacy has become an urgent issue in the modern quality assessment of TCM formulas.The quality marker has emerged as a crucial standard in this field,achieving notable success in recent years.This paper reviews recent progress in the development of the quality marker system in TCM by highlighting strategies based on the correlation between efficacy and constituents,using analytical techniques to investigate the material basis and efficacy of TCM.However,the aforementioned methods inevitably involve human selection factors.With the widespread application of artificial intelligence learning algorithms,it is now possible to develop a modern quality evaluation method for the multicomponent“efficacyquality”correlation in TCM formulas.This approach leverages artificial intelligence techniques to explore novel and quantifiable methods for scientific and rational quality control in TCM formulas.In this paper,important future directions and questions in this field are also discussed.

关 键 词：quality of traditional Chinese medicine quality marker EFFICACY artificial intelligence 

分 类 号：R73[医药卫生—肿瘤]