卵巢透明细胞癌275例临床病理学分析  

Ovarian clear cell carcinoma:a clinicopathological analysis of 275 cases

作　　者：杜则玲 侯宁[2] 张喆[2] 史传兵 DU Zeling*;HOU Ning;ZHANG Zhe;SHI Chuanbing(Department of Obstetrics and Gynaecology,Nanjing Pukou Traditional Chinese Medicine Hospital Affiliated to China Pharmaceutical University,Nanjing,Jiangsu 210000,China;不详)

机构地区：[1]中国药科大学附属南京市浦口中医院妇产科,江苏南京210000 [2]江苏省肿瘤医院病理科,江苏南京210009 [3]南京市浦口人民医院病理科,江苏南京211800

出　　处：《中国临床研究》2025年第3期433-436,440,共5页Chinese Journal of Clinical Research

基　　金：浦口区社会事业科技发展及软科学项目(S2024-8)。

摘　　要：目的 研究卵巢透明细胞癌(OCCC)的临床病理学特点。方法 筛选江苏省肿瘤医院病理科及江苏省人民医院浦口分院病理科2004年1月至2023年9月的275例OCCC病例,分析275例OCCC的病理形态学、免疫组织化学,并对40例OCCC行高频突变基因检测。结果 肿瘤由乳头状、管囊状及实性结构组成。瘤细胞胞质透明或嗜酸性,核大,核仁明显。核分裂2~5/10个高倍视野。34.9%(96/275)的病例检出子宫内膜异位病变。免疫组织化学检测,瘤细胞特异性表达肝细胞核因子1β(HNF-1β, 268/275)和天冬氨酸肽酶A(NapsinA, 270/275)。二代基因测序检测发现特异性的突变基因ARID1A(21/40)、PIK3CA(18/40)、TERT(9/40)、PTEN(7/40)、MSI(3/40)和TP53(6/40)。结论 OCCC是一种独特的卵巢肿瘤,诊断和鉴别诊断依赖于病理组织形态学、免疫表型与分子遗传学。Objective To identify the clinicopathologic characteristics in ovarian clear cell carcinoma(OCCC).Methods A total of 275 cases of OCCC from the Department of Pathology at Jiangsu Cancer Hospital and the Pukou Branch of Jiangsu Province Hospital from January 2004 to September 2023 was selected.The pathological morphology and immunohistochemistry of these 275 OCCC cases were analyzed and high-frequency mutation gene testing on 40 OCCC cases was detected.Results OCCC exhibited a combination of various patterns:papillary,tubulocystic,and solid.The tumor cells had transparent or eosinophilic cytoplasm,large nuclei,and prominent nucleoli.Mitoses were typically observed at a rate of 2 to 5 per 10 high power fields.Endometriosis was identified in 34.9%(96/275)of OCCC patients.Immunohistochemically,the neoplastic cells consistently expressed HNF-1β(268/275)and NapsinA(270/275).Next-generation sequencing detected specific mutated genes:ARID 1 A(21/40),PIK 3 CA(18/40),TERT(9/40),PTEN(7/40),MSI(3/40),and TP 53(6/40).Conclusion OCCC is a distinct type of ovarian carcinoma.The diagnosis and differential diagnosis of OCCC require an integrated approach involving pathomorphology,immunophenotype,and molecular genetics.

关 键 词：卵巢透明细胞癌 病理形态 免疫组织化学 分子遗传学 基因检测 

分 类 号：R737.31[医药卫生—肿瘤]