膳食支链氨基酸摄入与结直肠癌患者糖脂代谢关系的研究  

cnStudy on the relationship between dietary branched-chain amino acid intake and glucose lipid metabolism in patients with colorectal cancer

作　　者：王颖 薛红妹 谢颖[2] 李增宁[1,3] Wang Ying;Xue Hongmei;Xie Ying;Li Zengning(School of Public Health,Hebei Medical University,Shijiazhuang 050000,Hebei,China;Department of Clinical Nutrition,the First Hospital of Hebei Medical University,Hebei Key Laboratory of Nutrition and Health,Shijiazhuang 050031,Hebei,China;Hospital of Stomatology Hebei Medical University,Shijiazhuang 050017,Hebei,China)

机构地区：[1]河北医科大学公共卫生学院,河北石家庄050000 [2]河北医科大学第一医院营养科,河北省营养与健康重点实验室,河北石家庄050031 [3]河北医科大学口腔医院,河北石家庄050017

出　　处：《肿瘤代谢与营养电子杂志》2025年第1期68-75,共8页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：河北医科大学第一医院星火项目(XH202316);河北医科大学研究生创新资助项目(XCXZZS202303)。

摘　　要：目的探讨膳食支链氨基酸摄入量与结直肠癌患者糖脂指标之间的关系,以期为改善患者糖脂代谢紊乱提供理论依据。方法自常见恶性肿瘤患者营养状况与临床结局相关性研究(INSCOC)及常见恶性肿瘤患者膳食摄入量及其影响因素的现况研究数据库中依据纳入、排除标准筛选结直肠癌患者,本研究纳入研究对象为345例结直肠癌患者,研究起止时间为2019年1月至2020年1月。对其进行膳食问卷调查及一般信息、实验室指标等数据信息收集,运用多重线性回归、多因素Logistic回归分析。结果多重线性回归分析结果显示,日均膳食支链氨基酸摄入量可以显著负向预测空腹血糖(FPG)异常、总胆固醇(TC)异常、高密度脂蛋白胆固醇(HDL-C)异常情况。多因素Logistic回归分析结果显示,各类膳食支链氨基酸的中、高等摄入量均为FPG异常发生的保护因素。调整混杂因素后,日均亮氨酸的中等摄入量患者发生TC异常的风险是低等摄入量患者的2.07倍,而日均膳食支链氨基酸的中、高等摄入量为保护因素。日均亮氨酸、日均缬氨酸的中、高等摄入量是甘油三酯(TG)异常的保护因素;日均异亮氨酸的高等摄入量为保护因素。日均膳食支链氨基酸的中等摄入量是HDL-C异常的保护因素。日均膳食支链氨基酸的中等摄入量低密度脂蛋白胆固醇(LDL-C)异常的风险是低等摄入量的3.60倍。结论较高的膳食支链氨基酸摄入量与结直肠癌患者的糖脂代谢指标异常之间更多的是保护因素,但日均亮氨酸的中等摄入量组于TC异常,日均膳食支链氨基酸的中等摄入量是LDL-C异常的危险因素。Objective To investigate the relationship between dietary branched-chain amino acid intake and glycolipid indices in patients with colorectal cancer in order to provide a theoretical basis for ameliorating glycolipid metabolism disorders in patients.Method Colorectal cancer patients were selected according to the inclusion and exclusion criteria from the databases of the Multicentre Study on Nutritional Status and Clinical Outcomes of Common Malignant Tumors in China(INSCOC study)and the Current Status of Dictary Intake and Its Influencing Factors in Patients with Common Malignant Tumors.Dietary questionnaires,general information,laboratory indicators and other data were collected and analyzed using multiple linear regression and multifactorial Logistic regression.Result The results of the multiple linear regression analysis revealed that the average daily intake of branched-chain amino acids(BCAA)in the diet could significantly and negatively predict the levels of fasting blood glucose(FPG),total cholesterol(TC),and high-density lipoprotein cholesterol(HDL-C).Abnormal total cholesterol and abnormal abnormal high density lipoprotein cholesterol(HDL-C).Multivariate Logistic analysis showed that moderate and high intakes of various branched-chain amino acids in the diet were protective factors for the occurrence of FPG abnormalities.After adjusting for confounding,the risk of abnormal TC was 2.07 times higher in the moderate daily leucine intake group than in the low intake group,and the protective factor was the moderate and high daily dietary branched-chain amino acid intake group.Triglyceride(TG)abnormalities were a protective factor in the medium and high daily intake groups of leucine and valine.The higher daily intake of isoleucine was the protective factor.Average daily intake of branched-chain amino acids was a protective factor for HDL-Cabnormalities.The risk of abnormal low density lipoprotein cholesterol(LDL-C)was 3.60 times higher in the moderate daily intake group than in the low intake group.Conclusio

关 键 词：支链氨基酸 膳食摄入量 结直肠癌 糖脂代谢紊乱 亮氨酸 异亮氨酸 缬氨酸 危险因素 

分 类 号：R15[医药卫生—营养与食品卫生学]