Inhibition of ITGA2 suppresses cervical tumorigenesis and metastasis by targeting the AKT/mTOR signaling pathway  

作　　者：Haixia Luo Jingjing Chang Yiting Ren Xiu Zhang Yuanxing Li Miao Huo Hongyuan Wang Xin Yang Jianbing Liu Qingmei Zhang Yueyang Zhao Wei Wang 

机构地区：[1]Department of Obstetrics and Gynecology,The Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China [2]Pathology Department,School of Medicine,Stanford University,California 94305,USA [3]School of Basic Medical Sciences,Shanxi Medical University,Taiyuan,Shanxi 030001,China [4]School of Applied Science,Taiyuan University of Science and Technology,Taiyuan,Shanxi 030024,China

出　　处：《Genes & Diseases》2025年第2期86-89,共4页基因与疾病(英文)

基　　金：supported by grants from the Applied Basic Research Program of Shanxi,China (No.20210302123277);the Key Research and Development Program of Shanxi,China (No.201903D321152);the National Natural Science Foundation of China (No.82373107).

摘　　要：Cervical cancer(CCa)is a substantial global health concern,and its lymph node metastasis(LNM)significantly diminishes patients'survival rates.1 Hence,a thorough investigation into the molecular mechanisms driving this progression is vital.Integrin alpha 2(ITGA2)plays critical roles in various tumorigenic processes via cancer-related signaling pathways.

关 键 词：METASTASIS ITG cancer 

分 类 号：R73[医药卫生—肿瘤]