Reactive oxygen species mediate ovarian cancer development,platinum resistance,and angiogenesis via CXCL8 and GSK-3β/p70S6K1 axis  

作　　者：Jiange Qiu Qing Xu Tahira Panah A K M Helal Morshed Xue Wang Fengmei Zhou Wenjing Liu Jufeng Wang Ye Zhang Bingjie Liu Bing-Hua Jiang 

机构地区：[1]The First Affiliated Hospital of Zhengzhou University,The Academy of Medical Science,Zhengzhou University,Zhengzhou,Henan 450000,China [2]Department of Pathology,Nanjing Medical University,Nanjing,Jiangsu210029,China [3]The Affiliated Cancer Hospital of Zhengzhou University,Academy of Medical Science,Zhengzhou University,Zhengzhou,Henan 450000,China

出　　处：《Genes & Diseases》2025年第2期133-135,共3页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China (No.81903174,82073393);the Provincial Health Commission of Henan,China (No.SBGJ202003013,LHGJ20190656);the Medical Science and Technology Research Plan Provincial Co-construction Project of Henan Province,China (No.SBGJ202302023);the Medical Science and Technology Project of Henan Province,China (No.SB201901110).

摘　　要：Ovarian cancer is one of the leading causes of cancerrelated deaths in women worldwide,with a five-year overall survival rate of less than 50%or30%if it is in the advanced stages.1 Reactive oxygen species(ROS)are typi:cally involved in signal transduction and gene activation.2 Recent studies suggest increased levels of RoS in cancer development,3,4 but the role and mechanism of Ros in ovarian cancer angiogenesis and development remain to be elucidated.

关 键 词：ANGIOGENESIS cancer PLATINUM 

分 类 号：R73[医药卫生—肿瘤]