The interplay between RNA m^(6)A modification and radiation biology of cancerous and non-cancerous tissues:a narrative review  

作　　者：Yajia Cheng Yue Shang Shuqin Zhang Saijun Fan 

机构地区：[1]State Key Laboratory of Advanced Medical Materials and Devices,Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Tianjin Institutes of Health Science,Institute of Radiation Medicine,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China

出　　处：《Cancer Biology & Medicine》2024年第12期1120-1140,共21页癌症生物学与医学(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(Grant No.82173467 and 82273577);CAMS Innovation Fund for Medical Sciences(Grant Nos.CIFMS,2022-I2M-2-003 and 2021-I2M-1-042).

摘　　要：The diverse radiation types in medical treatments and the natural environment elicit complex biological effects on both cancerous and non-cancerous tissues.Radiation therapy(RT)induces oncological responses,from molecular to phenotypic alterations,while simultaneously exerting toxic effects on healthy tissue.N^(6)-methyladenosine(m^(6)A),a prevalent modification on coding and non-coding RNAs,is a key epigenetic mark established by a set of evolutionarily conserved enzymes.The interplay between m^(6)A modification and radiobiology of cancerous and non-cancerous tissues merits in-depth investigation.This review summarizes the roles of m^(6)A in the biological effects induced by ionizing radiation and ultraviolet(UV)radiation.It begins with an overview of m^(6)A modification and its detection methods,followed by a detailed examination of how m^(6)A dynamically regulates the sensitivity of cancerous tissues to RT,the injury response in non-cancerous tissues,and the toxicological effects of UV exposure.Notably,this review underscores the importance of novel regulatory mechanisms of m^(6)A and their potential clinical applications in identifying epigenetically modulated radiation-associated biomarkers for cancer therapy and estimation of radiation dosages.In conclusion,enzyme-mediated m^(6)A-modification triggers alterations in target gene expression by affecting the metabolism of the modified RNAs,thus modulating progression and radiosensitivity in cancerous tissues,as well as radiation effects on normal tissues.Several promising avenues for future research are further discussed.This review highlights the importance of m^(6)A modification in the context of radiation biology.Targeting epi-transcriptomic molecules might potentially provide a novel strategy for enhancing the radiosensitivity of cancerous tissues and mitigating radiation-induced injury to normal tissues.

关 键 词：Radiation biology m^(6)A modification epi-transcriptome CANCER non-cancer 

分 类 号：R730[医药卫生—肿瘤]