Aqueous humor adipokine profile of primary open angle glaucoma patients and cataract patients with or without metabolic disorders  

作　　者：Zi-Yao Xia Ke Xu Wei-Jia Zhang De-Fu Wu Zhe Pan Hao-Cheng Xian Xue-Min Li Huai-Zhou Wang Chun Zhang 

机构地区：[1]Department of Ophthalmology,Peking University Third Hospital,Beijing 100191,China [2]Beijing Key Laboratory of Restoration of Damaged Ocular Nerve,Peking University Third Hospital,Beijing 100191,China [3]Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China [4]Beijing Tsinghua Changgung Hospital Eye Center,Beijing Tsinghua Changgung Hospital,Tsinghua Medicine,Tsinghua University,Beijing 102218,China [5]Beijing Visual Science and Translational Eye Research Institute(BERI),Beijing 102218,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第4期615-626,共12页国际眼科杂志(英文版)

基　　金：Supported by National Key R&D Program of China(No.2023YFC2506100);the Changping Key Research Project of the Beijing Natural Science Foundation Program(No.L234016).

摘　　要：AIM:To investigate the role of adipokines in primary open angle glaucoma(POAG)by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorders.METHODS:In this cross-sectional study,aqueous humor samples of 22 eyes of POAG patients(POAG group),24 eyes of cataract patients without metabolic disorders(cataract group),and 24 eyes of cataract patients with metabolic disorders(cataract+metabolic disorders group)were assessed for 15 adipokines by Luminex bead-based multiplex array.The correlation between aqueous humor adipokines and clinical indicators of POAG was analyzed and compared across the groups.RESULTS:The analysis revealed that the levels of adiponectin,leptin,adipsin,retinol-binding protein 4(RBP4),angiopoietin-2,angiopoietin-like protein 4(ANGPTL4),chemokine(C-C motif)ligand 2(CCL2),interleukin-8(IL-8),and interleukin-18(IL-18)in the aqueous humor of the POAG group were significantly higher than those in the cataract group.Additionally,the level of angiopoietin-2 in the POAG group was higher than in the cataract+metabolic disorders group.However,no significant correlation was found between the levels of adipokines in the POAG group and intraocular pressure(IOP),severity of POAG,or the use of glaucoma medications.CONCLUSION:This study demonstrates significant differences in aqueous humor adipokine levels between POAG and cataract patients.The findings suggest that the levels of aqueous humor adipokines may reflect the inflammatory states in POAG and systemic metabolic abnormalities.

关 键 词：glaucoma biomarkers ADIPOKINE primary open angle glaucoma aqueous humor metabolic disorder 

分 类 号：R73[医药卫生—肿瘤]