Effect of resistant starch supplementation on the diversity and composition of human gut microbiota:a systematic review and meta-analysis  

作　　者：Jiaxin Xu Haocun Kong Caiming Li Xiaofeng Ban Zhaofeng Li 

机构地区：[1]State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China [2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]Institute of Future Food Technology,Jiangsu Industrial Technology Research Institute,Yixing 214200,China

出　　处：《Food Science and Human Wellness》2025年第3期850-863,共14页食品科学与人类健康(英文)

基　　金：financially supported by the National Key R&D Program of China(2022YFF1100600,2022YFF1100605);the Science and Technology Support Program(Modern Agriculture)of Jiangsu Province(BE2022323);the National Natural Science Foundation of China(32302011)。

摘　　要：Resistant starch(RS)has attracted much researchers'attention because of its health-beneficial effects.Gut microbiota obviously shapes human health,but the effects of RS supplementation on the changes of human gut microbiota remain unclear.This observational meta-analysis aimed to reveal the effects of RS intake onα-diversity and composition of gut microbiota through meta-analysis.Two independent authors systematically searched articles from inception until February 2023 on four electronic databases.Twenty-four highly relevant trials were included conforming to Preferred Reporting Items for Systematic reviews and MetaAnalysis protocol,and a total of 816 individuals were included.Significant heterogeneity analyses revealed that RS intake notably decreased Shannon index(weighted mean difference(WMD):-0.11;95%confidence interval(CI):-0.21,-0.01),and stimulated the composition of health promoting bacteria genera,including Bifidobacterium(relative abundance:WMD:1.75;95%CI:0.39,3.11;bacterial populations:WMD:0.36;95%CI:0.04,0.69),Faecalibacterium(relative abundance:WMD:0.70;95%CI:0.20,1.20;fold change:effect size:0.91;95%CI:0.60,1.23),and Prevotella(relative abundance:WMD:0.35;95%CI:0.01,0.69).Taken together,the present study revealed that changes in the gut microbiota diversity and genera were correlated with RS supplementation,which may contribute to benefits in human health.

关 键 词：Resistant starch Gut microbiota META-ANALYSIS HUMAN 

分 类 号：R57[医药卫生—消化系统]