Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity  

作　　者：Heng Yin Meng Liu Yaling Zhao Haitao Wu Danna Zheng Zhenhui Guo Ying Zhou Shaofeng Wu Chuanbing Chen Lei Zhang Shanshan Song Yanli He Ren Zhang 

机构地区：[1]Research Centre of Basic Integrative Medicine,School of Basic Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China [2]Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510006,China [3]The First Affi liated Hospital of Jinan University,Guangzhou 510006,China [4]School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China [5]Integrated Hospital of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510315,China [6]Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China

出　　处：《Food Science and Human Wellness》2025年第2期651-661,共11页食品科学与人类健康(英文)

基　　金：supported by Natural Science Foundation of Guangdong Province,China(2022A1515011575);National Natural Science Foundation of China,China(81873154);President Foundation of Integrated Hospital of Traditional Chinese Medicine,Southern Medical University,China(1202103010)。

摘　　要：Lycii Radicis Cortex(LRC)is a medicinal and food homologous plant with various pharmacological activities,including anti-tumor effects.This study explores the anti-tumor effect of LRC on non-small cell lung cancer(NSCLC)and its molecular mechanism using mice bearing Lewis lung carcinoma cells.LRC significantly suppressed the growth of NSCLC.Besides,RNA sequencing of mice tumors and hematoxylin&eosin and immunofluorescence staining revealed that LRC promoted the infiltration of T lymphocytes,specifically GZMB~+CD8~+T lymphocytes,in tumor tissues.The Gene Set Enrichment Analysis of spleen RNA indicated that LRC up-regulated PD-1-downstream pathways,suggesting that LRC exerted its effects through the PDL1/PD-1 pathway.Further experiments revealed that LRC interacted with PD-L1,blocking PD-L1/PD-1 binding and thus restoring the T cell killing activity on tumor cells.Together,these results support using LRC as healthy food to improve anti-tumor immunity in patients with NSCLC.

关 键 词：Lycii Radicis Cortex Non-small cell lung cancer PD-L1 Immune checkpoint 

分 类 号：R73[医药卫生—肿瘤]