Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration  

作　　者：Yu Wang Shanshan Jin Yaru Guo Yilong Lu Xuliang Deng 

机构地区：[1]Department of Orthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing,China [2]Department of Pediatric Dentistry,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing,China [3]Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China

出　　处：《International Journal of Oral Science》2025年第1期98-111,共14页国际口腔科学杂志(英文版)

基　　金：supported by the National Key Research and Development Program of China 2021YFA1207304;he National Natural Science Foundation of China 82221003,81991505,U22A20160,82201123,82100980 and 82201020;eijing Nova Program Z211100002121043,China Postdoctoral Science Foundation 2021M700279,2021M700281;tate Key Laboratory of Oral Diseases;Sichuan University SKLOD2023OF01。

摘　　要：Regenerating periodontal bone defect surrounding periodontal tissue is crucial for orthodontic or dental implant treatment.The declined osteogenic ability of periodontal ligament stem cells(PDLSCs)induced by inflammation stimulus contributes to reduced capacity to regenerate periodontal bone,which brings about a huge challenge for treating periodontitis.Here,inspired by the adhesive property of mussels,we have created adhesive and mineralized hydrogel microspheres loaded with traditional compound cordycepin(MMS-CY).MMS-CY could adhere to the surface of alveolar bone,then promote the migration capacity of PDLSCs and thus recruit them to inflammatory periodontal tissues.Furthermore,MMS-CY rescued the impaired osteogenesis and ligamentforming capacity of PDLSCs,which were suppressed by the inflammation stimulus.Moreover,MMS-CY also displayed the excellent inhibitory effect on the osteoclastic activity.Mechanistically,MMS-CY inhibited the premature senescence induced by the inflammation stimulus through the nuclear factor erythroid 2-related factor(NRF2)pathway and reducing the DNA injury.Utilizing in vivo rat periodontitis model,MMS-CY was demonstrated to enhance the periodontal bone regeneration by improving osteogenesis and inhibiting the osteoclastic activity.Altogether,our study indicated that the multi-pronged approach is promising to promote the periodontal bone regeneration in periodontitis condition by reducing the inflammation-induced stem cell senescence and maintaining bone homeostasis.

关 键 词：PERIODONTAL INFLAMMATION IMPAIRED 

分 类 号：R78[医药卫生—口腔医学]