Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy  

作　　者：Ming Hao Xingchen Li Xinxin Zhang Boqiang Tao He Shi Jianing Wu Yuyang Li Xiang Li Shuangji Li Han Wu Jingcheng Xiang Dongxu Wang Weiwei Liu Guoqing Wang 

机构地区：[1]Department of Oral and Maxillofacial Surgery,Hospital of Stomatology,Jilin University,Changchun,China [2]Laboratory Animal Center,College of Animal Science,Jilin University,Changchun,China [3]State Key Laboratory of Supramolecular Structure and Material,College of Chemistry,Jilin University,Changchun,China [4]State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases,Key Laboratory for Zoonosis Research of the Ministry of Education,College of Basic Medical Science,Jilin University,Changchun,China

出　　处：《International Journal of Oral Science》2025年第1期112-121,共10页国际口腔科学杂志(英文版)

基　　金：supported by the Science and Technology Projects of Jilin Provincial Department of Science and Technology(Grant/Award Numbers:20240305037YY);National Key Research and Development Program of China(2021YFC2400603);the Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20269);the Jilin University young teachers and students cross-disciplinary training project(Grant No.2023-JCXK-08,2024-JCXK-07)。

摘　　要：Tongue squamous cell carcinoma(TSCC)is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion.Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients.The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy.Nanoparticles with diagnostic and photothermal therapeutic properties may offer a new approach for the targeted therapy of TSCC.However,inadequate accumulation of photosensitizers at the tumor site diminishes the efficacy of photothermal therapy(PTT).This study modified gold nanodots(AuNDs)with the TSCC-targeting peptide HN-1 to improve the selectivity and therapeutic effects of PTT.The Au-HN-1 nanosystem effectively targeted the TSCC cells and was rapidly delivered to the tumor tissues compared to the AuN Ds.The enhanced accumulation of photosensitizing agents at tumor sites achieved significant PTT effects in a mouse model of TSCC.Moreover,owing to its stable long-term fluorescence and high X-ray attenuation coefficient,the Au-HN-1 nanosystem can be used for fluorescence and computed tomography imaging of TSCC,rendering it useful for early tumor detection and accurate delineation of surgical margins.In conclusion,Au-HN-1 represents a promising nanomedicine for imaging-based diagnosis and targeted PTT of TSCC.

关 键 词：DIAGNOSIS SQUAMOUS INVASION 

分 类 号：R73[医药卫生—肿瘤]