GnIH secreted by green light exposure,regulates bone mass through the activation of Gpr147  

作　　者：Yu You Konglin Huo Liang He Tongyue Wang Lei Zhao Rong Li Xiaoqing Cheng Xuebin Ma Zhiying Yue Stefan Siwko Ning Wang Lujian Liao Mingyao Liu Jian Luo 

机构地区：[1]Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,East China Normal University,Shanghai,PR China [2]Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center),Tongji University School of Medicine,Shanghai,PR China [3]Precision Research Center for Refractory Diseases,Shanghai General Hospital,Shanghai Jiaotong University,School of Medicine,Shanghai,PR China [4]Department of Translational Medical Sciences,Institute of Biosciences and Technology,Texas A&M University Health Science Center,Houston,TX,77030,USA [5]Leicester Cancer Research Centre,Department of Genetics and Genome Biology,University of Leicester,Leicester,UK [6]Division of Clinical Medicine,School of Medicine and Population Health,University of Sheffield,Sheffield,UK

出　　处：《Bone Research》2025年第1期212-223,共12页骨研究(英文版)

基　　金：National Key Research and Development Program of China(2023YFB3810200 to J.L.);National Natural Science Foundation of China(92168204,82225030 to J.L.);Fundamental Research Funds for the Central Universities(22120210586 to J.L.)。

摘　　要：Reproductive hormones associated with the hypothalamic-pituitary-gonadal(HPG)axis are closely linked to bone homeostasis.In this study,we demonstrate that Gonadotropin inhibitory hormone(GnIH,one of the key reproductive hormones upstream of the HPG axis)plays an indispensable role in regulating bone homeostasis and maintaining bone mass.We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density(BMD)in mice primarily by enhancement of osteoclast activation in vivo and in vitro.Mechanistically,GnIH/Gpr147 inhibits osteoclastogenesis by the PI3K/AKT,MAPK,NF-κB and Nfatc1 signaling pathways.Furthermore,GnIH treatment was able to alleviate bone loss in aging,ovariectomy(OVX)or LPS-induced mice.Moreover,the therapy using green light promotes the release of GnIH and rescues OVX-induced bone loss.In humans,serum GnIH increases and bone resorption markers decrease after green light exposure.Therefore,our study elucidates that GnIH plays an important role in maintaining bone homeostasis via modulating osteoclast differentiation and demonstrates the potential of GnIH therapy or green light therapy in preventing osteoporosis.

关 键 词：ACTIVATION HOMEOSTASIS GNIH 

分 类 号：S83[农业科学—畜牧学]