National Natural Science Foundation of China,Grant/Award Number:82101937;Guangdong Medical Science and Technology Research Fund Project,China,Grant/Award Number:B2024069;Guangzhou Science and Technology Plan Project,China,Grant/Award Number:2024A04J4923 and SL2023A04J02229。
Background:Makorin ring finger protein 3 gene(MKRN3)gene mutation is the most common genetic cause of central precocious puberty(CPP)in children.Due to the lack of ideal MKRN3-modified animal model(MKRN3-modified mice...
National Key Research and Development Program of China(2023YFB3810200 to J.L.);National Natural Science Foundation of China(92168204,82225030 to J.L.);Fundamental Research Funds for the Central Universities(22120210586 to J.L.)。
Reproductive hormones associated with the hypothalamic-pituitary-gonadal(HPG)axis are closely linked to bone homeostasis.In this study,we demonstrate that Gonadotropin inhibitory hormone(GnIH,one of the key reproducti...