Rebamipide in gastric mucosal protection and healing:An Asian perspective  

作　　者：Manish Kak 

机构地区：[1]Department of Gastroenterology,Manipal Hospital,Ghaziabad 201002,Uttar Pradesh,India

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2025年第1期25-36,共12页世界胃肠药理与治疗学杂志(英文)

摘　　要：This review emphasizes the exemplary safety and efficacy of rebamipide in the treatment of gastric ulcers and other mucosa-related disorders,positioning it as a viable candidate for inclusion in treatment guidelines across India and globally.An in-depth literature review of rebamipide was carried out on PubMed and Google Scholar.Rebamipide has a multifaceted mechanism of action,including prostaglandin synthesis,scavenging free radicals,and enhancing mucin produc-tion,leading to enhanced mucosal protection and ulcer healing.Rebamipide serves as a highly effective and safe treatment option for gastric ulcers and gas-troesophageal reflux disease.The efficacy of this drug in treating ulcers often surpasses that of routinely used agents such as pantoprazole,sucralfate,misop-rostol,famotidine,lansoprazole,and esomeprazole.This superiority of rebami-pide can be attributed to the low rate of adverse events associated with it and its mild side effects,contributing to its widespread adoption across Southeast Asia and Russia.This popularity extends to its application beyond gastrointestinal ailments.Notably,it has been successfully employed in the treatment of ophthal-mological,oncological,and bone regeneration-related issues.Rebamipide's exemplary safety and efficacy in treating gastric ulcers and other mucosa-related disorders support its potential for inclusion in treatment guidelines,not only in India but also globally.

关 键 词：REBAMIPIDE Peptic ulcer Gastroesophageal reflux disease Mucosal protection TREATMENT 

分 类 号：R57[医药卫生—消化系统]