Construction of a risk prediction model for postoperative cognitive dysfunction in colorectal cancer patients  

作　　者：Zhen-Ping Zheng Yong-Guo Zhang Ming-Bo Long Kui-Quan Ji Jin-Yan Peng Kai He 

机构地区：[1]Department of Anesthesiology,The People’s Hospital of Qian Nan,Duyun 558000,Guizhou Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第4期221-232,共12页世界胃肠外科杂志(英文)

基　　金：Supported by the Research Fund of Qiannan Medical College for Nationalities,No.Qnyz202222.

摘　　要：BACKGROUND Colorectal cancer(CRC)is one of the most prevalent and lethal malignant tumors worldwide.Currently,surgical intervention was the primary treatment modality for CRC.However,increasing studies have revealed that CRC patients may experience postoperative cognitive dysfunction(POCD).AIM To establish a risk prediction model for POCD in CRC patients and investigate the preventive value of dexmedetomidine(DEX).METHODS A retrospective analysis was conducted on clinical data from 140 CRC patients who underwent surgery at the People’s Hospital of Qian Nan from February 2020 to May 2024.Patients were allocated into a modeling group(n=98)and a validation group(n=42)in a 7:3 ratio.General clinical data were collected.Additionally,in the modeling group,patients who received DEX preoperatively were incorporated into the observation group(n=54),while those who did not were placed in the control group(n=44).The incidence of POCD was recorded for both cohorts.Data analysis was performed using statistical product and service solutions 20.0,with t-tests orχ2 tests employed for group comparisons based on the data type.Least absolute shrinkage and selection operator regression was applied to identify influencing factors and reduce the impact of multicollinear predictors among variables.Multivariate analysis was carried out using Logistic regression.Based on the identified risk factors,a risk prediction model for POCD in CRC patients was developed,and the predictive value of these risk factors was evaluated.RESULTS Significant differences were observed between the cognitive dysfunction group and the non-cognitive dysfunction group in diabetes status,alcohol consumption,years of education,anesthesia duration,intraoperative blood loss,intraoperative hypoxemia,use of DEX during surgery,intraoperative use of vasoactive drugs,surgical time,systemic inflammatory response syndrome(SIRS)score(P<0.05).Multivariate Logistic regression analysis identified that diabetes[odds ratio(OR)=4.679,95%confidence interval(CI)=1.382-15.833],al

关 键 词：Colorectal cancer POSTOPERATIVE Cognitive dysfunction ANESTHESIA Risk prediction model DEXMEDETOMIDINE Preventive value 

分 类 号：R73[医药卫生—肿瘤]