Long non-coding RNA in the regulation of cell death in hepatocellular carcinoma  

作　　者：Jiang Wang Zi-Xuan Liu Zhi-Hong Huang Jie Wen Zhou-Zhou Rao 

机构地区：[1]Children Medical Center,Hunan Provincial People's Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha 410013,Hunan Province,China [2]Department of Pediatric Orthopedics,Hunan Provincial People's Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha 410013,Hunan Province,China [3]Department of Physiology,Hunan Normal University School of Medicine,Changsha 410003,Hunan Province,China

出　　处：《World Journal of Clinical Oncology》2025年第4期9-20,共12页世界临床肿瘤学杂志(英文)

基　　金：Supported by Science Project of Hunan Provincial Healthy Commission,No.20230844.

摘　　要：Hepatocellular carcinoma(HCC)is the predominant form of primary liver cancer,accounting for 90%of all cases.Currently,early diagnosis of HCC can be achieved through serum alpha-fetoprotein detection,B-ultrasound,and computed tomography scanning;however,their specificity and sensitivity are suboptimal.Despite significant advancements in HCC biomarker detection,the prognosis for patients with HCC remains unfavorable due to tumor heterogeneity and limited understanding of its pathogenesis.Therefore,it is crucial to explore more sensitive HCC biomarkers for improved diagnosis,monitoring,and management of the disease.Long non-coding RNA(lncRNA)serves as an auxiliary carrier of genetic information and also plays diverse intricate regulatory roles that greatly contribute to genome complexity.Moreover,investigating gene expression regulation networks from the perspective of lncRNA may provide insights into the diagnosis and prognosis of HCC.We searched the PubMed database for literature,comprehensively classified regulated cell death mechanisms and systematically reviewed research progress on lncRNA-mediated cell death pathways in HCC cells.Furthermore,we prospectively summarize its potential implications in diagnosing and treating HCC.

关 键 词：Hepatocellular carcinoma Long non-coding RNA NECROSIS Apoptosis Iron death AUTOPHAGY Cell death 

分 类 号：R73[医药卫生—肿瘤]