Hypochloremia is an underutilised prognostic marker in patients with advanced liver cirrhosis and liver failure  

作　　者：Jinit R Soni Sudheer Marrapu Ramesh Kumar 

机构地区：[1]Department of Gastroenterology,All India Institute of Medical Sciences,Patna 801507,India

出　　处：《World Journal of Hepatology》2025年第3期42-49,共8页世界肝病学杂志(英文)

摘　　要：Patients with advanced liver cirrhosis and liver failure frequently experience abnormalities in their serum electrolyte levels.In such patients,hyponatremia has been identified as a predictor of poor outcomes.However,emerging evidence suggests that serum chloride may provide even better prognostic information in similar situations.Hypochloremia,characterised by low serum chloride levels,has been linked to increased mortality,exacerbated organ dysfunction,and higher requirements for renal replacement therapy and vasopressors in various critical conditions,including advanced liver diseases.The pathophysiological mecha-nisms underlying the association between low serum chloride levels and poor outcomes in liver disease appear to involve complex interactions among electro-lyte imbalances,renal function,and systemic hemodynamics.Chloride dysregu-lation can influence renal salt-sensing mechanisms,disrupt acid-base homeostasis,and exacerbate complications such as hepatic encephalopathy and hepatorenal syndrome.This article aims to elucidate the prognostic significance of lower serum chloride levels in patients with advanced liver disease.By reviewing recent literature and analysing clinical data,we seek to establish serum chloride as an underutilised but valuable prognostic marker.Understanding the role of serum chloride in liver disease could enhance prognostic accuracy,refine treatment strategies,and ultimately improve patient outcomes.

关 键 词：CHLORIDE Hypochloremia Liver failure CIRRHOSIS HYPONATREMIA PROGNOSIS 

分 类 号：R73[医药卫生—肿瘤]