中国10~24岁青少年双相障碍疾病负担现状及趋势分析  

Analysis of disease burden for bipolar disorder in Chinese adolescents aged 10-24 years and trend prediction

作　　者：赵子赫 朱嘉雯 黄倩玲 曾智 ZHAO Zihe;ZHU Jiawen;HUANG Qianling;ZENG Zhi(School of Health Economics and Management,Nanjing University of Chinese Medicine,Nanjing(210023),Jiangsu Province,China)

机构地区：[1]南京中医药大学卫生经济管理学院,江苏210023

出　　处：《中国学校卫生》2025年第2期266-271,共6页Chinese Journal of School Health

基　　金：国家自然科学基金项目(82101602)。

摘　　要：目的 分析1990—2021年中国10~24岁青少年双相障碍疾病负担状况及变化趋势,为双相障碍的防治工作提供理论依据。方法 选取全球疾病负担(GBD)数据库2021年的最新数据,使用Joinpoint回归模型、年龄—时期—队列(APC)模型和贝叶斯年龄—时期—队列(BAPC)模型对中国青少年双相障碍标化发病率和标化失能调整寿命年(DALY)率等指标进行分析和预测,并计算平均年度变化百分比(AAPC)。结果 1990—2021年青少年双相障碍疾病总体标化发病率(1990年:22.92/10万,2021年:23.17/10万)呈上升趋势(AAPC=0.03,t=8.20,P<0.01),标化DALY率(1990年:33.61/10万,2021年:33.76/10万)变化趋势较为平缓(AAPC=0.01,t=0.99,P=0.32)。1990—2021年女生标化发病率和标化DALY率均大于男生(χ^(2)=16.38,P<0.01)。1990—2021年中国10~24岁青少年双相障碍发病率和DALY率的净漂移值分别为-0.23%和-0.22%。中国10~24岁青少年双相障碍发病率在15~19岁最高,为33.14/10万;20~24岁DALY率最高,为57.26/10万。中国10~24岁青少年双相障碍发病风险和DALY风险RR值均在2017—2021年达到最低,分别为0.99(95%CI=0.97~1.00)和0.98(95%CI=0.97~0.99)(P值均<0.05)。中国10~24岁青少年双相障碍发病风险和DALY风险RR值均在2000—2004年出生队列达到最低,均为0.86(95%CI=0.84~0.87)(P值均<0.05)。预计2022—2031年中国10~24岁青少年双相障碍总体标化发病率和标化DALY率均呈上涨趋势,到2031年分别涨至24.10/10万和34.90/10万。结论 1990—2021年中国青少年双相障碍标化发病率和标化DALY率均呈上涨趋势。应重点关注女性青少年群体,控制15~19岁青少年双相障碍标化发病率和20~24岁青少年双相障碍标化DALY率,增强对青少年双相障碍的关注和筛查。Objective To analyze the burden of bipolar disorder among adolescents aged 10-24 in China from 1990 to 2021 and its trend of change,so as to provide theoretical basis for the prevention and treatment of bipolar disorder.Methods The latest data from the Global Burden of Disease(GBD)database in 2021 were selected.The Joinpoint regression model,age-period-cohort(APC)model,and bayesian age-period-cohort(BAPC)model were used to analyze and predict indicators such as the age-standardized incidence rate and age-standardized disability-adjusted life year(DALY)rate of bipolar disorder among Chinese adolescents,and the average annual percent change(AAPC)was calculated.Results From 1990 to 2021,the overall age-standardized incidence rate(1990:22.92/100000,2021:23.17/100000)showed an upward trend(AAPC=0.03,t=8.20,P<0.01)and change trend of age-standardized DALY rate(1990:33.61/100000,2021:33.76/100000)was relatively flat(AAPC=0.01,t=0.99,P=0.32).From 1990 to 2021,age-standardized incidence rate and age-standardized DALY rate of girls were higher than boys(χ^(2)=16.38,P<0.01).The net drift values for the incidence rate and DALY rate of bipolar disorder among Chinese adolescents aged 10-24 years were-0.23%and-0.22%,respectively.The highest incidence rate of bipolar disorder among Chinese adolescents aged 10-24 years was observed in the 15-19 age group,with a rate of 33.14/100000;the highest DALY risk was in the 20-24 age group,with a rate of 57.26/100000.The lowest incidence risk and DALY risk RR values for bipolar disorder among Chinese adolescents aged 10-24 years were observed in 2017-2021,with RR values of 0.99(95%CI=0.97-1.00)and 0.98(95%CI=0.97-0.99),respectively(P<0.05).Similarly,the lowest incidence risk and DALY risk RR values for this age group were observed in the 2000-2004 birth cohort,both of which were 0.86(95%CI=0.84-0.87)(P<0.05).It was projected that the overall age-standardized incidence rate and age-standardized DALY rate of bipolar disorder among Chinese adolescents aged 10-24 years will continue to increa

关 键 词：双相障碍 患病代价 失能调整生命年 青少年 

分 类 号：R179[医药卫生—妇幼卫生保健] B844.2[医药卫生—公共卫生与预防医学] R174.6[哲学宗教—发展与教育心理学]