Exosomal biomarkers: A novel frontier in the diagnosis of gastrointestinal cancers  

作　　者：Yuan Zhang Ning-Ning Yue Li-Yu Chen Cheng-Mei Tian Jun Yao Li-Sheng Wang Yu-Jie Liang Dao-Ru Wei Hua-Lin Ma De-Feng Li 

机构地区：[1]Department of Gastroenterology,Shenzhen People’s Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518000,Guangdong Province,China [2]Department of Medical Administration,Huizhou Institute for Occupational Health,Huizhou 516000,Guangdong Province,China [3]Department of Gastroenterology,Shenzhen People’s Hospital(The Second Clinical Medical College,Jinan University),Shenzhen 518000,Guangdong Province,China [4]Department of Emergency,Shenzhen People’s Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518000,Guangdong Province,China [5]Department of Gastroenterology,Shenzhen People’s Hospital(Jinan University of Second Clinical Medical Sciences),Shenzhen 518000,Guangdong Province,China [6]Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen 518000,Guangdong Province,China [7]Department of Rehabilitation,Shenzhen People’s Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518000,Guangdong Province,China [8]Department of Nephrology,The Second Clinical Medical College,Jinan University,Shenzhen 518020,Guangdong Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2025年第4期42-66,共25页世界胃肠肿瘤学杂志(英文)

摘　　要：Gastrointestinal(GI)cancers,which predominantly manifest in the stomach,colorectum,liver,esophagus,and pancreas,accounting for approximately 35%of global cancer-related mortality.The advent of liquid biopsy has introduced a pivotal diagnostic modality for the early identification of premalignant GI lesions and incipient cancers.This non-invasive technique not only facilitates prompt therapeutic intervention,but also serves as a critical adjunct in prognosticating the likelihood of tumor recurrence.The wealth of circulating exosomes present in body fluids is often enriched with proteins,lipids,microRNAs,and other RNAs derived from tumor cells.These specific cargo components are reflective of processes involved in GI tumorigenesis,tumor progression,and response to treatment.As such,they represent a group of promising biomarkers for aiding in the diagnosis of GI cancer.In this review,we delivered an exhaustive overview of the composition of exosomes and the pathways for cargo sorting within these vesicles.We laid out some of the clinical evidence that supported the utilization of exosomes as diagnostic biomarkers for GI cancers and discussed their potential for clinical application.Furthermore,we addressed the challenges encountered when harnessing exosomes as diagnostic and predictive instruments in the realm of GI cancers.

关 键 词：EXOSOMES Exosomal cargo Liquid biopsy Biomarkers Gastrointestinal malignancies Gastrointestinal tumor diagnosis 

分 类 号：R73[医药卫生—肿瘤]