Personalized treatment selection in colorectal cancer with peritoneal metastasis: Do we need statistically validated indicators or cultural shift?  

作　　者：Fabrizio D'Acapito Massimo Framarini Daniela Di Pietrantonio Giorgio Ercolani 

机构地区：[1]General and Oncologic Surgery,Morgagni-Pierantoni Hospital,AUSL Romagna,Forli 47121,Emilia-Romagna,Italy [2]Department of Medical and Surgical Sciences,University of Bologna,Bologna 40126,Emilia-Romagna,Italy

出　　处：《World Journal of Gastrointestinal Oncology》2025年第4期553-556,共4页世界胃肠肿瘤学杂志(英文)

摘　　要：The study by Wu et al analyzed the correlation between nutritional and inflam-matory markers and prognosis in patients with colorectal cancer peritoneal metastasis.The authors propose the neutrophil-to-lymphocyte ratio(NLR)as a predictor of overall survival(OS)and developed a nomogram incorporating NLR,hemoglobin(Hb),and peritoneal cancer index(PCI)to estimate 1-and 2-year survival.Although the nomogram shows high accuracy,the group of patients analyzed is heterogeneous with respect to the surgical treatment received,and no clear definitions are given for normal Hb and there is no reason for choosing a very high PCI(≥20).Patient selection for cytoreductive surgery with hyper-thermic intraperitoneal chemotherapy requires a multidisciplinary approach.Over-simplification of the selection pathway may deny access to curative treatments to patients who could benefit.While methodologically sound,the study does not consider the effect of treatment received on OS,thus introducing a potential bias.

关 键 词：Colorectal cancer Peritoneal metastasis INFLAMMATION NUTRITION Biomarkers Prognosis Overall survival Cytoreductive surgery 

分 类 号：R73[医药卫生—肿瘤]