任务态功能MRI用于非自杀性自伤发病机制研究进展  

Research progresses of task state functional MRI in pathogenesis of non-suicidal self-injury

作　　者：彭诗集 刘念[1,2,3] 李颖 李航宇 余锐 廖开科 陈馨悦 PENG Shiji;LIU Nian;LI Ying;LI Hangyu;YU Rui;LIAO Kaike;CHEN Xinyue(Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;School of Medical Imaging,North Sichuan Medical College,Nanchong 637000,China;Sichuan Key Laboratory of Functional and Molecular Imaging,Chengdu 610000,China)

机构地区：[1]川北医学院附属医院放射科,四川南充637000 [2]川北医学院医学影像学院,四川南充637000 [3]功能与分子影像四川省重点实验室,四川成都610000

出　　处：《中国医学影像技术》2025年第3期494-497,共4页Chinese Journal of Medical Imaging Technology

基　　金：中央引导地方四川省科技发展项目(2024ZYD0272);功能与分子影像四川省重点实验室开放课题(SCU-HM-202307001);南充市市校科技战略合作项目(22SXQT0305)。

摘　　要：非自杀性自伤(NSSI)指以自伤行为为主而无自杀意图的精神障碍,发病机制尚不明确,可能与奖赏环路异常、痛觉处理异常、情绪管理障碍、冲动控制障碍及下丘脑-垂体-肾上腺轴系统失调等有关。任务态功能MRI(fMRI)有助于理解NSSI不同任务状态或行为下的内在联系和神经环路机制。本文就任务态fMRI用于NSSI发病机制研究进展进行综述。Non-suicidal self-injury(NSSI)refers to a mental disorder characterized by deliberate self-harm behaviors without suicidal intent.The pathogenesis of NSSI remains unclear,but may be related to abnormalities in reward circuitry,pain processing,emotion regulation,impulse control and hypothalamic-pituitary-adrenal axis.Task state functional MRI(fMRI)provides valuable insights into the intrinsic connections and neural circuits mechanisms underlying NSSI during various task states or behaviors.Research progresses of task state fMRI in pathogenesis of NSSI were reviewed in this article.

关 键 词：青少年 自我伤害行为 磁共振成像 

分 类 号：R749[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]