Photo-Driven In Situ Solidification of Whole Cells through Inhibition of Trogocytosis for Immunotherapy  

作　　者：Hao Liu Ke Huang Hao Zhang Xiaohui Liu Hui Jiang Xuemei Wang 

机构地区：[1]State Key Laboratory of Digital Medical Engineering,School of Biological Science and Medical Engineering,Southeast University,Nanjing,Jiangsu 210096,China

出　　处：《Research》2024年第4期301-312,共12页研究(英文)

基　　金：supported by the National Natural Science Foundation of China(82061148012,82027806,and 21974019);the National Key Research and Development Program of China(2017YFA0205300);the Primary Research&Development Plan of Jiangsu Province(BE2019716)。

摘　　要：Achieving antitumor immunotherapy based on hybridization of multiple types of inactivated cells has attracted a lot of attention.However,the hybridized cells of disordered structure could result in the shedding of antigens and their transfer to immune cells,which suppresses tumor immunity through trogocytosis.Here,we report a strategy for in situ solidification of tumor whole cell by biomineralization for sustained stimulation of antitumor immunity.

关 键 词：SUSTAINED IMMUNITY STIMULATION 

分 类 号：R73[医药卫生—肿瘤]