多系统萎缩伴神经原性直立性低血压多学科协作康复一例  

Multiple System Atrophy with Neurogenic Orthostatic Hypotension:A Multidisciplinary Collaborative Rehabilitation Case Report

作　　者：张宇航 王含[2] 丁荣晶 ZHANG Yuhang;WANG Han;DING Rongjing(Department of Rehabilitation Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院康复医学科,北京100730 [2]中国医学科学院北京协和医院神经科,北京100730

出　　处：《协和医学杂志》2025年第2期448-453,共6页Medical Journal of Peking Union Medical College Hospital

基　　金：国家自然科学基金(82171255);中央高水平医院临床科研专项(2022-PUMCH-B-018,2023-PUMCH-E-005)。

摘　　要：多系统萎缩(multiple system atrophy,MSA)是一种罕见的、成年起病的进行性神经系统变性疾病。临床上根据运动表型不同,将MSA分为帕金森型和小脑型。MSA起病隐匿,早期常表现为自主神经功能障碍而易误诊。神经原性直立性低血压(neurogenic orthostatic hypotension,nOH)是原发性神经系统退行性疾病中慢性自主神经衰竭的关键表现,是MSA患者最常见的自主神经功能障碍,然而目前针对MSA患者伴nOH的治疗方法有限。本文报告1例MSA伴nOH患者的多学科协作康复治疗方案,旨在为此类患者的临床康复提供借鉴。Multiple system atrophy(MSA)is a rare with its adult onset progressive neurodegenerative disease,which is clinically classified into parkinsonian(MSA⁃P)and cerebellar(MSA⁃C)subtypes based on the presenting motor phenotype.MSA has an insidious onset,with its early manifestation of autonomic dysfunc⁃tion so is easily misdiagnosed.Neurogenic orthostatic hypotension(nOH)is a key manifestation of chronic auto⁃nomic failure in primary neurodegenerative diseases,and is the most common autonomic dysfunction in patients with MSA.Currently,the treatments for nOH in patients with MSA are limited.In this case report,the rehabili⁃tation method is shared for nOH in patients with MSA,which provides ideas for clinical treatment and rehabili⁃tation of nOH in these patients.

关 键 词：罕见病 多系统萎缩 神经原性直立性低血压 康复 

分 类 号：R741[医药卫生—神经病学与精神病学] R742[医药卫生—临床医学]