Potential benefits of Nigella Sativa(black seeds)in the management of“Chandipura virus infection”–an insight  

作　　者：Naina Mohamed Pakkir Maideen 

机构地区：[1]Clinical Associate Professor of Pharmacology,College of Medicine,Mohammed Bin Rashid University of Medicine and Health Sciences,Dubai,UAE

出　　处：《Food and Health》2025年第2期3-14,共12页食品和健康(英文)

摘　　要：The Chandipura vesiculovirus(CHPV),a single-stranded,negative sense RNA arbovirus with five structural proteins-the G,N,M,P,and L proteins-is the source of Chandipura virus infection.Children between the ages of 9 months and 14 years old are the most common recipients of CHPV infection,which is primarily spread by sand flies(Sergentomyia,Phlebotomus species).The potential advantages of black seeds(N.sativa)in the treatment of patients with CHPV infection are the main topic of our current review.The majority of patients infected with CHPV experience neurological complications such as encephalitis and other neurological complications.Since there is currently no approved antiviral treatment,supportive care and symptomatic therapy are the primary methods used to manage CHPV-infected patients.Herbal candidates possessing antioxidant,immunomodulatory,antiviral,and anti-inflammatory qualities may aid in the treatment of CHPV infection.The antiviral,anti-inflammatory,antioxidant,and immunomodulatory qualities of black seeds(N.sativa)have been shown in a number of preclinical and clinical investigations;these attributes could be helpful in the treatment of CHPV infection.Black seeds(N.sativa)may help treat CHPV-infected patients in the early stages of their illness when used in conjunction with symptomatic therapy and supportive care.In patients infected with CHPV,additional randomized controlled clinical trials would assess the efficacy and safety of black seeds(N.sativa).

关 键 词：Chandipura virus ENCEPHALITIS Nigella Sativa black seeds black cumin seeds THYMOQUINONE antiviral anti-inflammatory antioxidant IMMUNOMODULATORY 

分 类 号：R73[医药卫生—肿瘤]