阑尾切除术与结直肠癌发病风险关联的孟德尔随机化研究  

A mendelian randomization study on the association between appendectomy and the risk of colorectal cancer

作　　者：常宇 胡云峰[1] 王会丰[2] 郭静 张跳 郝雅琴 刘雨 CHANG Yu;HU Yunfeng;WANG Huifeng;GUO Jing;ZHANG Tiao;HAO Yaqin;LIU Yu(Department of Radiotherapy,Yan'an University Affiliated Hospital,Yan'an 716000,Shaanxi,China;Department of Gastroenterology,Yan'an University Affiliated Hospital,Yan'an 716000,Shaanxi,China)

机构地区：[1]延安大学附属医院放射治疗科,陕西延安716000 [2]延安大学附属医院消化内科,陕西延安716000

出　　处：《山东大学学报(医学版)》2025年第2期77-83,94,共8页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金(82060452);延安市科技计划项目(2022SLSFGG-036)。

摘　　要：目的采用两样本孟德尔随机化(mendelian randomization,MR)方法在遗传水平上探究阑尾切除术与结直肠癌之间的因果关系。方法采用逆方差加权法(inverse variance weighted,IVW)、MR Egger、加权中位数、简单模式和加权模式等方法进行分析。利用全基因组关联研究(genome-wide association study,GWAS)汇总数据,评估阑尾切除术与结直肠癌之间的因果关系。采用留一法、Cochran?s Q检验,MR-Egger回归截距项检验、MR-PRESSO检验进行敏感性分析,评估工具变量的异质性、多效性和稳定性。结果随机效应IVW结果显示,阑尾切除术与结直肠癌无遗传因果关系(OR=1.13,95%CI:0.29~4.36,P=0.86)。MR Egger、加权中位数、简单模式和加权模式的分析结果与随机效应IVW一致。无异质性、水平多效性。MR分析结果不受单个SNP的影响。结论阑尾切除术与结直肠癌在遗传水平上无因果关系。Objective To explore the causal relationship between appendectomy and colorectal cancer at the genetic level by a two-sample Mendelian randomization(MR).Methods The analysis was conducted using methods such as inverse variance weighting(IVW),MR Egger,weighted median,and both simple and weighted modes.Using summary data from genome-wide association studies(GWAS),the causal relationship between appendectomy and colorectal cancer was assessed.Sensitivity analyses were performed using leave-one-out analysis,Cochran's Q test,MR-Egger regression intercept test,and MR-PRESSO test to evaluate the heterogeneity,pleiotropy,and stability of the instrumental variables.Results The random-effects IVW results indicated that appendectomy hasd no genetic causal relationship with colorectal cancer(OR=1.13,95%CI:0.29-4.36,P=0.86).The analysis results from MR Egger,weighted median,simple mode,and weighted mode were consistent with those of the random-effects IVW.There was no heterogeneity,horizontal pleiotropy.The MR analysis results were not influenced by any single SNP.Conclusion There is no causal relationship between appendectomy and colorectal cancer at the genetic level.

关 键 词：阑尾切除术 结直肠癌 孟德尔随机化 遗传水平 因果推断 

分 类 号：R735.34[医药卫生—肿瘤]