The Tricarboxylic Acid Cycle Metabolites for Cancer:Friend or Enemy  

作　　者：Jie Wu Nian Liu Jing Chen Qian Tao Qiuqiu Li Jie Li Xiang Chen Cong Peng 

机构地区：[1]The Department of Dermatology,Xiangya Hospital,Central South University,Changsha,Hunan,China [2]Furong Labratory,Changsha,Hunan,China [3]Hunan Key Laboratory of Skin Cancer and Psoriasis,Hunan Engineering Research Center of Skin Health and Disease,Xiangya Hospital,Central South University,Changsha,Hunan,China [4]National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology,Changsha,Hunan,China [5]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan,China

出　　处：《Research》2025年第1期385-409,共25页研究(英文)

基　　金：supported by grant nos.82073458,82173424,81974476,and 82221002 from the National Natural Science Foundation;by grant from The Scientific Research Program of FuRong Laboratory(no.2023SK2103);by the Science and Technology Innovation Program of Hunan Province(2021RC4013);as well as the key project in Hunan province(2024JJ3052).

摘　　要：The tricarboxylic acid(TCA)cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions.Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position,the TCA cycle remains indispensable for tumor cells as a hub for the metabolic linkage and interconversion of glucose,lipids,and certain amino acids.TCA intermediates such as citrate,α-ketoglutarate,succinate,and fumarate are altered in tumors,and they regulate the tumor metabolism,signal transduction,and immune environment to affect tumorigenesis and tumor progression.This article provides a comprehensive review of the modifications occurring in tumor cells in relation to the intermediates of the TCA cycle,which affects tumor pathogenesis and current therapeutic strategy for therapy through targeting TCA cycle in cancer cells.

关 键 词：aerobic glycolysis tricarboxylic acid cycle tumor metabolic reprogramming amino acidstca tumor cells metabolic reprogramming ketoglutarate CITRATE 

分 类 号：R730.2[医药卫生—肿瘤]