膜分离纯化发酵乳酸工艺研究进展  

Research Progress in Purification of Lactic Acid in Fermentation Broth Based on Membrane Separation

作　　者：葛俊杰 李瑞林 郑勇 张旭 谭梦菲 田桂英 GE Junjie;LI Ruilin;ZHENG Yong;ZHANG Xu;TAN Mengfei;TIAN Guiying(Tianjin Key Laboratory of Brine Chemical Industry and Ecological Utilization of Resources,College of Chemical Engineering and Materials,Tianjin University&Technology,Tianjin 300457,China)

机构地区：[1]天津科技大学化工与材料学院,天津市卤水化工与资源生态化利用重点实验室,天津300457

出　　处：《当代化工》2025年第3期673-679,686,共8页Contemporary Chemical Industry

基　　金：国家自然科学基金项目(项目编号:52303245)。

摘　　要：微生物发酵法作为一种低成本的乳酸单体生产方式而成为最为主要的制备方法。鉴于发酵液中存在发酵底物、代谢产物和微生物残留物等杂质,如何高效低耗地从发酵液中提取乳酸单体备受关注。对多级分离膜分离特别是纳滤分离耦合其他技术在乳酸发酵液杂质膜法分离和乳酸提取中的应用效果进行了总结。同时,针对膜分离应用过程中存在的乳酸收率低、膜垢污染等问题进行了深入分析,旨在为规模化乳酸发酵的分离纯化提供参考依据。Microbial fermentation is the predominant method for producing lactic acid monomers due to its low cost.In view of the impurities such as fermentation substrate,metabolites and microbial residues in fermentation broth,how to extract lactic acid monomer from fermentation broth with high efficiency and low consumption has attracted much attention.In this paper,the effectiveness of multi-stage membrane separation,particularly nanofiltration coupled with other techniques,in the membrane-based separation of impurities and lactic acid extraction from lactic acid fermentation broths was summarized.Additionally,some problems such as low lactic acid recovery rate and membrane fouling encountered in membrane separation applications were analyzed,aiming to provide a reference basis for the purification of lactic acid fermentation processes.

关 键 词：发酵液 乳酸 分离纯化 膜分离 

分 类 号：TQ028.8[化学工程]