Lung metastases formed by disseminated tumor cells exhibit different proliferation states  

作　　者：Jiajun Liu Shihui Liu Jianhui Tian Jiaxuan Li Minghua Li Zujun Que 

机构地区：[1]Institute of Oncology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China [2]Clinical Oncology Center,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China

出　　处：《Acta Biochimica et Biophysica Sinica》2025年第2期321-324,共4页生物化学与生物物理学报(英文版)

基　　金：supported by the grants from the National Natural Science Foundation of China(Nos.82174245 and 82174017);Shanghai Frontier Research Base of Disease and Syndrome Biology of Inflammatory Cancer Transformation(No.2021KJ03-12);the Traditional Chinese Medicine Science and Technology Development Project of Shanghai Medical Innovation&Development Foundation(No.WL-HBRC-2021001K).

摘　　要：Lung cancer is the leading cause of cancer mortality in China and worldwide[1,2],and metastasis is the main cause of patient death[3].Cancer cells invade and migrate from the primary tumor,enter the circulation system through intravasation,and become circulating tumor cells(CTCs).CTCs that survive in blood vessels extravasate and invade target organs to become disseminated tumor cells(DTCs).DTCs proliferate in target organs to metastasize to distant organs[3].The previous view was that metastasis is the final stage of cancer progression.Normal cells first transform into tumor cells and then into invasive cancer cells;thus,metastasis occurs.Therefore,the possibility of metastasis is closely related to the size of the primary tumor.This is reflected in the TNM stage(T,tumor size;N,extent of spread to regional lymph nodes;M,metastasis to distant organs),which is often referenced in clinical diagnosis.However,an increasing number of studies are currently challenging this view.A previous study showed that the metastasis of malignant tumors occurs in the early stages of cancer.When patients are diagnosed with primary cancer,dissemination occurs.

关 键 词：ORGANS LUNG METASTASIS 

分 类 号：R73[医药卫生—肿瘤]