Structures and mechanisms of the RNA m^(6)A writer  

作　　者：Ting Deng Jinbiao Ma 

机构地区：[1]State Key Laboratory of Genetic Engineering,Collaborative Innovation Centre of Genetics and Development,Department of Biochemistry and Biophysics,Institute of Plant Biology,School of Life Sciences,Fudan University,Shanghai 200438,China

出　　处：《Acta Biochimica et Biophysica Sinica》2025年第1期59-72,共14页生物化学与生物物理学报(英文版)

摘　　要：N^(6)-methyladenosine(m^(6)A)is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA metabolism.The m^(6)A writer for mRNAs and long non-coding RNAs consists of the catalytic subunit m^(6)A-METTL complex(MTC)(including METTL3/METTL14)and the regulatory subunit m^(6)A-METTL-associated complex(MACOM)(including HAKAI,WTAP,VIRMA,ZC3H13,and RBM15/15B).In this review,we focus on recent advances in our understanding of the structural and functional properties of m^(6)A writers and the possible mechanism by which they recognize RNA substrates and perform selective m^(6)A modifications.

关 键 词：6) WRITER MECHANISMS 

分 类 号：R73[医药卫生—肿瘤]