Spatiotemporally-controlled supramolecular hybrid nanoassembly enabling ferroptosis-augmented photodynamic immunotherapy of cancer  

作　　者：Yuequan Wang Congtian Wu Chengcheng Feng Qin Chen Zhonggui He Shenwu Zhang Cong Luo Jin Sun 

机构地区：[1]Department of Pharmaceutics,Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Joint International Research Laboratory of Intelligent Drug Delivery Systems,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China [3]Department of Pharmacy,Cancer Hospital of China Medical University,Liaoning Cancer Hospital&Institute,Shenyang 110042,China

出　　处：《Chinese Chemical Letters》2025年第3期379-384,共6页中国化学快报(英文版)

基　　金：financially supported by the National Natural Science Foundation of China(No.82161138029);the Basic Research Projects of Liaoning Provincial Department of Education(No.LJKZZ20220109);the Shenyang Youth Science and Technology Innovation Talents Program(No.RC210452).

摘　　要：Photodynamic therapy(PDT)not only directly eradicates tumor cells but also boosts immunogenicity,promoting antigen presentation and immune cell infiltration.However,the robust antioxidant defense mechanisms within tumor cells significantly weaken the efficacy of photodynamic immunotherapy.Herein,a supramolecular hybrid nanoassembly is constructed by exploring the synergistic effects of the photodynamic photosensitizer(pyropheophorbide a,PPa)and the ferroptosis inducer(erastin).The erastinmediated inhibition of system X_(c)−significantly downregulates glutathione(GSH)expression,amplifying intracellular oxidative stress,leading to pronounced cell apoptosis,and promoting the release of damageassociated molecular patterns(DAMPs).Additionally,the precise cooperation of PPa and erastin enhances ferroptosis efficiency,exacerbating the accumulation of lipid peroxides(LPOs).Ultimately,LPOs serve as a“find me”signal,while DMAPs act as an“eat me”signal,collectively promoting dendritic cell maturation,enhancing infiltration of the cytotoxic T lymphocytes,and eliciting a robust immune response.This study opens new horizons for enhancing tumor immunotherapy through simultaneous ferroptosis-PDT.

关 键 词：SUPERMOLECULE Nanoasssembly Ferroptosis Photodynamic therapy IMMUNOTHERAPY 

分 类 号：R730.5[医药卫生—肿瘤]