嗜黏蛋白阿克曼菌对糖脂代谢和肠道健康的调控作用及机制研究进展  

Research Progress on Regulatory Effects and Mechanism of Akkermansia muciniphila on Glycolipid Metabolism and Intestinal Health

作　　者：席艺嘉 潘海羽 吴征林 许桂瑚 黎小银 高彦华 XI Yijia;PAN Haiyu;WU Zhenglin;XU Guihu;LI Xiaoyin;GAO Yanhua(Key Laboratory of Animal Science School of National Ethnic Affairs Commission of China,Key Laboratory of QinghaiTibetan Plateau Animal Genetic Resources Reservation and Utilization,College of Animal and Veterinary Sciences,Southwest Minzu University,Chengdu 610041,China)

机构地区：[1]西南民族大学畜牧兽医学院,青藏高原动物遗传资源保护与利用教育部重点实验室,动物科学国家民委重点实验室,四川成都610041

出　　处：《食品工业科技》2025年第8期431-440,共10页Science and Technology of Food Industry

基　　金：四川省科技计划项目(2023NSFSC1148);国家民委高等教育教学改革研究项目(23235);四川省大学生创新创业训练计划支持项目(S202310656096)。

摘　　要：嗜黏蛋白阿克曼菌(Akkermansia muciniphila,A.muciniphila)是一种功能性肠道共生菌,其在消化道中的分布及丰度的失衡与糖脂代谢紊乱及肠炎等多种疾病的发生密切相关。本文旨在对A.muciniphila在调节糖脂代谢、缓解肠道炎症和增强肠道屏障方面的益生功能及其中分子作用机制进行简要综述,同时针对目前A.muciniphila应用存在安全且有效的补充剂量范围待确定、低成本高密度工业化生产工艺待挖掘等问题展望未来,为进一步将A.muciniphila开发成为新型益生菌添加剂提供参考依据。Akkermansia muciniphila(A.muciniphila)is a functional gut commensal bacterium.The imbalance in the distribution and abundance of A.muciniphila in the gastrointestinal tract is closely related to the occurrence of various diseases,including glucolipid metabolic disorders and enteritis.This review aims to provide a concise overview of the probiotic function of A.muciniphila in regulating glucose and lipid metabolism,alleviating intestinal inflammation,and enhancing intestinal barrier function,as well as its molecular mechanism of action.Meanwhile,to tackle the challenges of industrial applying A.muciniphila,such as defining a safe and effective supplemental dosage and creating a cost-efficient,high-density production process,new research directions are proposed to guide the development of A.muciniphila as a novel probiotic additive.

关 键 词：嗜黏蛋白阿克曼菌 益生菌 糖脂代谢 肠道健康 分子机制 

分 类 号：TS201.3[轻工技术与工程—食品科学]