The Efficacy of Whole-Course Local Simultaneous Integrated Boost Intensity-Modulated Radiotherapy in the Treatment of Locally Advanced Esophageal Cancer and Its Impact on Immune Function  

作　　者：Lei Yuan Yujuan Gao 

机构地区：[1]Tai’an Tumor Prevention and Treatment Hospital,Tai’an 271000,Shandong,China

出　　处：《Journal of Clinical and Nursing Research》2025年第3期224-230,共7页临床护理研究(英文)

摘　　要：Objective:To analyze the efficacy of whole-course local simultaneous integrated boost intensity-modulated radiotherapy(SIB-IMRT)on patients with locally advanced esophageal squamous cell carcinoma(ESCC).Methods:88 patients with ESCC admitted to the hospital between October 2022 and October 2024 were selected and randomly divided into two groups using a random number table.The experimental group received SIB-IMRT treatment,while the control group received conventional intensity-modulated radiotherapy(C-IMRT).The objective remission rate,immune function,tumor markers,and adverse reaction rate were compared between the two groups.Results:The objective remission rate in the experimental group was higher than that in the control group(P<0.05).Before treatment,there was no difference in immune function levels and tumor marker levels between the two groups(P>0.05).After treatment,the immune function levels in the experimental group were better than those in the control group,and the tumor marker levels were lower than those in the control group(P<0.05).The adverse reaction rate in the experimental group was lower than that in the control group(P<0.05).Conclusion:SIB-IMRT can improve the objective remission rate of patients with ESCC,protect their immune function,down-regulate tumor marker levels,and prevent side effects after treatment.

关 键 词：Whole-course local simultaneous integrated boost intensity-modulated radiotherapy Locally advanced esophageal squamous cell carcinoma EFFICACY Immune function 

分 类 号：R735.1[医药卫生—肿瘤]