基于CBCT图像构建牙颌面虚拟患者的两种配准方法比较  

Comparison of two registration methods for constructing virtual craniodentofacial patients based on cone beam computed tomography images

作　　者：叶嘉慧 王时敏 王子轩 刘云松[1] 孙玉春[3] 叶红强[1] 周永胜[1] YE Jiahui;WANG Shimin;WANG Zixuan;LIU Yunsong;SUN Yuchun;YE Hongqiang;ZHOU Yongsheng(Department of Prosthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&NHC Research Center of Engineering and Technology for Computerized Dentistry&NMPA Key Laboratory for Dental Materials,Beijing 100081,China;Center of Dental Laboratory,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&NHC Research Center of Engineering and Technology for Computerized Dentistry&NMPA Key Laboratory for Dental Materials,Beijing 100081,China;Center of Digital Dentistry,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&NHC Research Center of Engineering and Technology for Computerized Dentistry&NMPA Key Laboratory for Dental Materials,Beijing 100081,China)

机构地区：[1]北京大学口腔医学院·口腔医院修复科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,口腔数字医学北京市重点实验室,国家卫生健康委员会口腔医学计算机应用工程技术研究中心,国家药品监督管理局口腔材料重点实验室,北京100081 [2]北京大学口腔医学院·口腔医院义齿加工中心,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,口腔数字医学北京市重点实验室,国家卫生健康委员会口腔医学计算机应用工程技术研究中心,国家药品监督管理局口腔材料重点实验室,北京100081 [3]北京大学口腔医学院·口腔医院口腔医学数字化中心,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,口腔数字医学北京市重点实验室,国家卫生健康委员会口腔医学计算机应用工程技术研究中心,国家药品监督管理局口腔材料重点实验室,北京100081

出　　处：《北京大学学报(医学版)》2025年第2期354-359,共6页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金(81801015);北京大学口腔医院新技术新疗法项目(PKUSSNCT-20B07);国家重大疾病多学科合作诊疗能力建设项目(PKUSSNMP-201901);国家临床重点专科建设项目(PKUSSNKP-202117)。

摘　　要：目的:比较锥形束计算机体层摄影术(cone beam computed tomography,CBCT)数据参与构建牙颌面虚拟患者时,软组织配准法和牙列配准法的准确度。方法:选择13名需要行CBCT检查的患者,分别获取其数字牙列图像、配准印模三维图像、面部三维图像和颌面部数据。以配准印模三维图像为媒介建立包含牙列和面部软组织的牙面虚拟患者,将CBCT数据三维重建并形成包含面部软组织、颌骨和牙列的牙颌面虚拟患者,分别通过面中下部软组织标志点(软组织配准法)及牙列标志点(牙列配准法)将CBCT来源的牙颌面虚拟患者和配准印模法建立的牙面虚拟患者进行配准,选择口内扫描来源的数字牙列图像、面部扫描来源的面部三维图像和CBCT来源的颌骨图像建立2种牙颌面虚拟患者(隐藏CBCT来源的面部图像和牙列图像)。以配准印模法建立的牙面虚拟患者面部软组织为参考,对2种牙颌面虚拟患者中CBCT来源面部图像的面下1/2区域及面上1/2区域分别进行三维偏差分析,记录各组偏差的均方根误差(root mean square error,RMSE)。用配对t检验分别比较2种牙颌面虚拟患者中CBCT面部图像的面上1/2与面下1/2区域之间,以及面上1/2区域之间的RMSE差异是否有统计学意义。结果:配对t检验结果表明,2种牙颌面虚拟患者中CBCT来源面部图像的面上1/2与面下1/2区域之间的RMSE值差异无统计学意义(P>0.05),面上1/2区域软组织配准法的RMSE值小于牙列配准法[(1.696±0.420)mm vs.(1.752±0.424)mm,P<0.01]。结论:基于数字牙列图像、面部三维图像和CBCT来源颌骨图像建立牙颌面虚拟患者时,用软组织配准法将CBCT数据配准到牙面虚拟患者中的准确度较高。Objective:To compare the registration accuracy of cone beam computed tomography(CBCT)images while registering to virtual craniodentofacial patients based on soft tissue and the dentition registration method.Methods:Virtual dentofacial patients out of 13 selected participants who needed CBCT scanning were established by impression with a registered-block impression(RBI)based on digital dental images,three-dimensional(3D)facial images and maxillofacial CBCT images.CBCT images were processed in the Mimics software program,establishing the craniofacial virtual patients based on CBCT images(CCTs).Registration between virtual patients from RBI and CCT,using the soft tissue in lower half face(STE)and dentition(DTN)as the reference area,respectively,forming two kinds of virtual craniofacial patients based on digital dental images,3D facial images and skeletal images of CBCT(hiding the soft tissue and dental casts from CBCT).Three-dimensional deviation analysis was performed in the upper half face and lower half face of facial images from CBCT between two kinds of virtual craniodentofacial patients and compared with 3D facial images from RBI and recorded as root mean square error(RMSE).Paired-t test was used to compare the deviations of RMSEs between the upper and lower half of the face and the upper half of the face of facial images from CCT,respectively,between the two kinds of virtual craniodentofacial patients based on STE and DTN methods.Results:Paired-t tests showed that there was no statistically significant difference between the upper and lower half faces of facial images from CCT between STE and DTN(P>0.05),but the deviation of RMSEs of the upper half face of facial images from CCT in STE was smaller than those in DTN[(1.696±0.420)mm vs.(1.752±0.424)mm,P<0.01].Conclusion:The registration accuracy of CBCT registered in virtual craniodentofacial patients using soft tissue as the reference area was higher.

关 键 词：虚拟患者 锥形束计算机体层摄影术 牙颌面 牙面 配准 

分 类 号：R783.4[医药卫生—口腔医学]