EGF、EGFR、VEGF在甲状腺癌组织中的表达及其对淋巴结转移的预测价值  

Expression of EGF,EGFR and VEGF in Thyroid Cancer Tissues and Their Predictive Value for Lymph Node Metastasis

作　　者：马圆圆 籍胤玺[1] 徐娜[1] MA Yuanyuan;JI Yinxi;XU Na(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2025年第4期594-597,602,共5页The Practical Journal of Cancer

摘　　要：目的分析甲状腺癌患者EGF、EGFR、VEGF的表达水平及其对淋巴结转移的预测价值。方法收集100例甲状腺癌患者的临床资料。依照患者淋巴结转移情况分为转移组(19例)和非转移组(81例)。比较两组一般资料、EGF、EGFR、VEGF表达水平;分析EGF、EGFR、VEGF表达水平与甲状腺癌临床特征的关系,分析EGF、EGFR、VEGF的表达水平对甲状腺癌淋巴结转移的预测价值。结果两组性别、年龄、肿瘤直径、吸烟、饮酒比较,差异无统计学意义(χ^(2)=0.007,P=0.932、χ^(2)=0.124,P=0.725、χ^(2)=3.079,P=0.079、χ^(2)=0.061,P=0.805、χ^(2)=0.108,P=0.742);两组肿瘤分期差异显著(χ^(2)=7.022,P=0.008)。转移组EGF、EGFR、VEGF的表达水平均高于非转移组,差异有统计学意义(P<0.05)。EGF、EGFR、VEGF的表达与患者性别、年龄、肿瘤直径、吸烟、饮酒等无显著关系(P>0.05),与肿瘤分期Ⅲ+Ⅳ期有关(P<0.05)。将淋巴结转移=1,非淋巴结转移=0作为因变量,EGF、EGFR、VEGF作为自变量,进行二元逻辑回归分析,并进行受试者操作特征曲线(ROC)分析,结果显示,EGF、EGFR、VEGF三者联合预测甲状腺癌淋巴结转移的预测效能较高,ROC下面积(AUC)最大,为0.974,灵敏度为0.924,特异度为0.951。EGF、EGFR、VEGF的预测阈值分别为1.590μg/L、14.105 mg/L、238.375 pg/ml。结论EGF、EGFR、VEGF表达水平均在甲状腺癌淋巴结转移患者中异常增高,EGF、EGFR、VEGF表达水平对甲状腺癌淋巴结转移有良好的评估价值,可作为临床上评价淋巴结转移的评估因子。Objective The expression levels of EGF,EGFR and VEGF in patients with thyroid cancer and their predictive value to lymph node metastasis were analyzed.Methods Clinical data of 100 patients with thyroid cancer were collected.Patients with lymph node metastasis were divided into metastatic group(19 cases)and non-metastatic group(81 cases).The expression levels of EGF,EGFR and VEGF were compared between the 2 groups.To analyze the relationship between the expression levels of EGF,EGFR and VEGF and the clinical features of thyroid cancer,and to analyze the value of the expression levels of EGF,EGFR and VEGF in predicting lymph node metastasis of thyroid cancer.Results There was no significant difference in gender,age,tumor diameter,smoking and drinking between the two groups(χ^(2)=0.007,P=0.932,χ^(2)=0.124,P=0.725,χ^(2)=3.079,P=0.079,χ^(2)=0.061,P=0.805,χ^(2)=0.108,P=0.742).There was significant difference in tumor stage between the 2 groups(χ^(2)=7.022,P=0.008).The expression levels of EGF,EGFR and VEGF in metastasis group were higher than those in non-metastasis group,and the differences were statistically significant(P<0.05).The expressions of EGF,EGFR and VEGF were not significantly correlated with gender,age,tumor diameter,smoking and drinking(P>0.05),but were correlated with tumor stageⅢ+Ⅳ(P<0.05).Lymph node metastasis=1,non-lymph node metastasis=0 were used as dependent variables,and EGF,EGFR and VEGF were used as independent variables.Binary logistic regression analysis and receiver operating characteristic curve(ROC)analysis were performed.The results showed that the combination of EGF,EGFR and VEGF had high predictive efficacy in predicting lymph node metastasis of thyroid cancer.The area under ROC(AUC)was the largest(0.974),the sensitivity was 0.924,and the specificity was 0.951.The predicted thresholds of EGF,EGFR and VEGF were 1.590μg/L,14.105 mg/L and 238.375 pg/ml,respectively.Conclusion The expression levels of EGF,EGFR and VEGF are abnormally increased in patients with lymph node metastasi

关 键 词：甲状腺癌 EGF EGFR VEGF 淋巴结转移 预测 

分 类 号：R736.1[医药卫生—肿瘤]