Pro-Aging Metabolic Reprogramming:A Unified Theory of Aging  

作　　者：Zhiguo Wang Baofeng Yang 

机构地区：[1]Guangdong Provincial Key Laboratory for Mechanistic and Translational Research on Bidirectional Complications among Chronic Conditions,Jinan University,Guangzhou 510630,China [2]Central Laboratories,The First Affiliated Hospital,Jinan University,Guangzhou 511436,China [3]State Key Laboratory of Frigid Zone Cardiovascular Diseases(SKLFZCD),Research Center for Innovative Technology of Pharmaceutical Analysis,College of Pharmacy,Harbin Medical University,Harbin 150081,China

出　　处：《Engineering》2025年第1期37-43,共7页工程(英文)

摘　　要：Despite recent advances in understanding the biology of aging,the field remains fragmented due to the lack of a central organizing hypothesis.Although there are ongoing debates on whether the aging process is programmed or stochastic,it is now evident that neither perspective alone can fully explain the complexity of aging.Here,we propose the pro-aging metabolic reprogramming(PAMRP)theory,which integrates and unifies the genetic-program and stochastic hypotheses.This theory posits that aging is driven by degenerative metabolic reprogramming(MRP)over time,requiring the emergence of pro-aging substrates and triggers(PASs and PATs)to predispose cells to cellular and genetic reprogramming(CRP and GRP).

关 键 词：AGING Aging theory METABOLISM Metabolic reprogramming Pro-aging substrate Pro-aging trigger 

分 类 号：R73[医药卫生—肿瘤]